Role of cationic lipids for the formulation of lipoplexes
Journal Title: International Journal of Research in Pharmaceutical Science and Technology - Year 2018, Vol 1, Issue 1
Abstract
Cationic lipids are widely used for their advantages over viral gene transfer as they are non-immunogenic and their production is easy. The formation of cationic liposomes to lipoplexes with the help of cationic lipids has been done. Cationic lipids are often used in combination with helper lipids such as DOPE or cholesterol for defining their structural properties. The mode of lipoplex formation has been described in this review. This review also focuses on the parameters that affects the physico-chemical properties of lipoplexes describing their use for the cationic lipid based on the gene therapy purposes. The current status and various prospects for the transfection efficacy of lipoplexes is also been described.
Authors and Affiliations
Varsha singh, Pramod Kumar Sharma, Md. Aftab Alam
Keywords
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- EP ID EP548809
- DOI 10.33974/ijrpst.v1i1.1
- Views 59
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