Role of CBNAAT in diagnosis of Tuberculous Meningitis
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 2
Abstract
Tuberculous meningitis is one of the most severe forms of tuberculosis associated with high incidence of death and disability. Due to paucibacillary nature of CSF, it is difficult to demonstrate tubercle bacilli by the standard staining procedures which is the gold standard for diagnosis, thus leading to a large number of cases being undiagnosed or misdiagnosed. Now, it has further been complicated by the emergence of multidrug resistance. So, this study was done with the aim to know the role of CBNAAT in the diagnosis of tubercular meningitis. 62 patients were included in the study who had features suggestive of tubercular meningitis. According to the universal case definition, the patients were divided into probable, possible and definitive TBM. Out of 62 patients included in the study, 6(4%) were Definite TBM, 33(58%) were probable TB, 17(30%) were possible TBM and 5 (8%) were not TBM. Total 22 patients had M. TB detected in their CSF on CBNAAT, out of a total of 57 TBM patients. Out of these 22,1 was detected with Rifampicin resistance. The sensitivity of CBNAAT in our study was 38.6%. Hence because of its rapidity, simplicity, and sensitivity, CBNAAT(Gene Xpert MTB/RIF) technology is emerging as a novel and promising technique to diagnose tuberculous meningitis and rifampicin resistance, which was undiagnosed most of the time.
Authors and Affiliations
Ashi Singh1 , Amarendra K. Shukla2 , Rajwinder Kaur3 , N. C. Kajal4 , Nadia5 , Lakhvir Kaur6 , N. S. Neki 7
Keywords
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- EP ID EP552752
- DOI 10.22192/ijcrms.2018.04.02.011
- Views 141
- Downloads 0
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