ROLE OF CELL FREE FETAL DNA IN MATERNAL BLOOD - A PROSPECTIVE ROLE OF CΒS AND MTHFR GENE AS ANTENATAL GENETIC MARKER IN PREECLAMPSIA PATIENTS
Journal Title: International Journal of Genetics - Year 2011, Vol 3, Issue 2
Abstract
The pathophysiology of cell - free fetal DNA in maternal blood of pre eclampsia patients remain inexplicable because of two main reasons- first presence of very minute quantity of cell free fetal DNA in plasma required sophisticated equipments & techniques for its identification and second is the variation in gestational age of the patients. Because of lacking molecular biology and associated “risk factors†involvement of CβS and MTHFR gene mutation is remain unidentified in such patients. Hence, the curiosity has been developing to understand the role of these genes in such cases to explore etiology of increasing risk in patients. In the present study, n=151 case were selected and 80% cases showed Sry positive (Y-chromosome specific sequence) used as marker for confirmation of cell free fetal DNA in maternal blood. Genetic study reveals, >20% case showing mutation of CβS gene and MTHFR C677T gene polymorphism showing lack of transition between C/T alleles. Statistical analysis showing significant difference due to hence, these findings could be useful to assess as prenatal diagnosis marker in genetics lead to altered single gene folic acid metabolism (homocysteine) and may increased as an independent “risk factor†in pre eclampsia patients.
Authors and Affiliations
A. K. SAXENA, GARIMA GUPTA, JYOTI GUPTA, SULEKHA PANDEY, L. K. PANDEY
Keywords
Related Articles
- EP ID EP170158
- DOI 10.9735/0975-2862.3.2.62-65
- Views 71
- Downloads 0
ISOLATION AND CHARACTERIZATION OF Proteus spp. FROM DOMESTIC DISPOSAL EXPRESSING EXTRACHROMOSOAL EXTENDED SPECTRUM β-LACTAMASE TRAIT
From a long time waterborne diseases have been major concern to living being. Handful countries have successfully implemented recycling of water. Recycling of water is under consideration in India. Indian rural region is...
EFFECT OF SALINITY AND DROUGHT STRESS ON GROWTH PARAMETERS, GLYCOSIDE CONTENT AND EXPRESSION LEVEL OF VITAL GENES IN STEVIOL GLYCOSIDES BIOSYNTHESIS PATHWAY OF Stevia rebaudiana (BERTONI)
Stevia [Stevia rebuaidana (Bertoni)], a family of Asteraceae is known to yield diterpenoid steviol glycosides (SGs) that is about 300 times sweeter than sugar. The present work examined the effects of different concentra...
Machine Learning Techniques: Approach for Mapping of MHC Class Binding Nonamers
The machine learning techniques are playing a major role in the field of immunoinformatics for DNA-binding domain analysis. Functional analysis of the binding ability of DNA-binding domain protein antigen peptides to maj...
HUMAN CHROMOSOMAL Q-HETEROCHROMATIN POLYMORPHISM AND ITS RELATION TO BODY HEAT CONDUCTIVITY
It is found that approximately 15-20% of non-coding part of human DNA is constitutive heterochromatin. There are two types of constitutive heterochromatin: C- and Q-heterochromatin. C-heterochromatin regions (C-HRs) are...
SECONDARY SEX RATIO IN A SOUTH-WESTERN NIGERIAN TOWN
In this study, the human secondary sex ratio (described as the number of males per 100 female births) in Ondo, a town in South -West Nigeria was analyzed using birth record between 2001 and 2008, obtained at State Specia...