ROLE OF CELL FREE FETAL DNA IN MATERNAL BLOOD - A PROSPECTIVE ROLE OF CΒS AND MTHFR GENE AS ANTENATAL GENETIC MARKER IN PREECLAMPSIA PATIENTS
Journal Title: International Journal of Genetics - Year 2011, Vol 3, Issue 2
Abstract
The pathophysiology of cell - free fetal DNA in maternal blood of pre eclampsia patients remain inexplicable because of two main reasons- first presence of very minute quantity of cell free fetal DNA in plasma required sophisticated equipments & techniques for its identification and second is the variation in gestational age of the patients. Because of lacking molecular biology and associated “risk factors†involvement of CβS and MTHFR gene mutation is remain unidentified in such patients. Hence, the curiosity has been developing to understand the role of these genes in such cases to explore etiology of increasing risk in patients. In the present study, n=151 case were selected and 80% cases showed Sry positive (Y-chromosome specific sequence) used as marker for confirmation of cell free fetal DNA in maternal blood. Genetic study reveals, >20% case showing mutation of CβS gene and MTHFR C677T gene polymorphism showing lack of transition between C/T alleles. Statistical analysis showing significant difference due to hence, these findings could be useful to assess as prenatal diagnosis marker in genetics lead to altered single gene folic acid metabolism (homocysteine) and may increased as an independent “risk factor†in pre eclampsia patients.
Authors and Affiliations
A. K. SAXENA, GARIMA GUPTA, JYOTI GUPTA, SULEKHA PANDEY, L. K. PANDEY
Keywords
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- EP ID EP170158
- DOI 10.9735/0975-2862.3.2.62-65
- Views 56
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