Role of Chemical Entities in Ototoxicity
Journal Title: Journal of Advanced Research in Medical Science & Technology - Year 2018, Vol 5, Issue 1
Abstract
A large number of medications have been identified as toxic to the ears. These adverse drug reactions vary from minor, reversible effects to serious, permanent impairment of hearing. Toxic effects on the structures of the inner ear include temporary or permanent ototoxicity resulting from adverse effect on the cochlea producing vertigo, ataxia, lightheadedness and other symptoms. The overall incidence of drug induced ototoxicity is unknown; however, drug induced deafness has been estimated to occur in 1.6 to 3 per 1000 medical patients. Recent studies revealed that arachidonic cascade and their metabolites are involved in maintaining inner ear function. Recent investigation suggests that the excessive use of aspirin causes tinnitus (ringing in the ear) in human being and impairment of the outer hair cell function in experimental animals. The view is that the Non-Steroidal Anti-inflammatory Drugs (NSAIDs) revealed protective effects against inner (cochlear) ear disorders. Knowledge of the potential toxic effects of drugs and of methods limiting toxicity will affect ototoxicity as well as characteristics of the toxic effects, risks factors, monitoring parameters, and management of adverse effects are reviewed in this review.
Authors and Affiliations
Dr. Vrish Dhwaj Ashwlayan,
Keywords
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