Role of copeptin in pediatric health and diseases
Journal Title: Innovations in Pharmaceuticals and Pharmacotherapy (IPP) - Year 2016, Vol 4, Issue 1
Abstract
Copeptin, a precursor of vasopressin is released when the hypothalamic-pituitary-adrenal axis (HPA) is activated in response to stress. Copeptin secretion from the posterior pituitary gland is in equimolar amounts with arginine vasopressin, hence it reflects arginine vasopressin concentration and can be used as surrogate biomarker of arginine vasopressin secretion. Measurement of copeptin levels has been shown to be useful in a variety of clinical scenarios. Therefore it can be used as a novel diagnostic and prognostic biomarker in pediatric diseases. The purpose of the present article is to highlight the role of copeptin as a prognostic marker in different pediatric illnesses where it may help in early detection and diagnostic accuracy.
Authors and Affiliations
Dr. Bandya Sahoo
Peroxisome proliferator-activated receptor-alpha agonists in the management of the diabetic acute kidney injury: Is the verdict out?
The growing evidences of diabetic acute kidney injury (AKI) suggested that diabetes is one of the detrimental causes. AKI is associated with glomerular hypertrophy, glomerulosclerosis, tubulointerstitial fibrosis, and me...
The importance of proteolytic enzymes: Revisiting to era
Proteolytic enzymes (also termed peptidases, proteases, and proteinases) are capable of hydrolyzing peptide bonds in proteins. They can be found in all living organisms, from viruses to animals and humans. Proteolytic en...
Pathogenesis and clinical significance of dermatophytes: A comprehensive review
Dermatophytes, a group of keratinophilic fungi thriving on the keratin substrate are the etiological agents responsible for causing cutaneous infections. Dermatophytosis currently treated with the commercially available...
Permeability assessment of drug substances using in vitro and ex vivo screening techniques
Solubility and permeability are two important parameters used for the evaluation of drug substance to assess its bioavailability. Although dissolution can be studied using official dissolution apparatus, there are no off...
Obesity management therapies
Obesity is prominently referred as a lifestyle disease that exhibits itself as one of the major health threat of this day. 65% of the world's population lives in developed countries where overweight and obesity kills mor...