Role Of Docetaxel Mems Device In The Treatment Of Diabetic Retinopathy
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2013, Vol 2, Issue 2
Abstract
Diabetic retinopathy is a micro-vascular complication composed of a characteristic group of lesions which occurs due to changes in the retinal circulation. It is increasingly becoming a major cause of blindness throughout the world in the age group of 20–60 years. Diabetic retinopathy is classified into two stages; Non-proliferative and proliferative. Due to the circulation problems, retinal hypoxia occurs leading to Angiogenesis. The new formed fragile blood vessels begin to grow in the retina, vitreous and may leak blood into the vitreous, clouding vision. If left untreated, proliferative diabetic retinopathy can cause severe vision loss and even blindness. The newly developed MEMS(Microelectromechanical system) device contains a microreservoir sealed by a polydimethylsiloxane membrane with a laser drilled aperture. By applying Magnetic field, the membrane deforms and releases the drug. Docetaxel inhibits Angiogenesis by inhibiting cell division and cell proliferation in Proliferative Diabetic Retinopathy and avoids vision loss. Thus Docetaxel improves quality of life of patients suffering with diabetic retinopathy besides treating the ovarian, prostate, liver, renal, gastric ,head and neck cancers.
Authors and Affiliations
M. Yogya sree harshini
Keywords
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