Role of ghrelin in exhaustive exercise- induced oxidative stress in rat Brain and liver
Journal Title: International Journal of Applied Exercise Physiology - Year 2013, Vol 2, Issue 1
Abstract
Strenuous exercise increases oxygen consumption and causes disturbance of intracellular pro-oxidant–antioxidant homeostasis. Ghrelin has been reported to possess free radical scavenging and antioxidant effect. in this study we aim to evaluate the beneficial effect of ghrelin on the oxidative stress and antioxidant enzyme systems in brain cortex and liver of rats after exhaustive swimming exercise. Sprague- Dawley rats (50) were subdivided into 3 main groups: control, exercise, exercise and ghrelin (50,100,200 ng) group. Animals in the two exercise groups swam for 5 days/week for 4 weeks. stress induced a decrease in the level of GSH and the activities of SOD, GST and catalase, while the levels of TBARS were found elevated. Ghrelin groups’ animals, especially G3 subgroup, have higher SOD, CAT, GSH and GST activity which reflect higher antioxidant enzyme activity and can be attributed to lower rates of oxidative stress which can be proved by reduced level of TBARS. The results of the study provides evidence that ghrelin pretreatment even in low dose reduces the level of lipid peroxidation and enhances the antioxidant defense against exercise-induced stress oxidative injury in rats’ vital organs like brain and liver.
Authors and Affiliations
Shereen M. Samir, Abeer F. Mostafa
Keywords
Related Articles
- EP ID EP567039
- DOI -
- Views 65
- Downloads 0
The effects of low impact aerobic exercise on acute phase proteins in older obese women with type П diabetes
Several studies have shown that adipose tissue plays an important role to produce large amounts of inflammatory cytokines such as IL-6 and CRP by the development of insulin resistance, diabetes and metabolic syndrome. Th...
The Effects of Trainings with Futsal Ball on Dribbling and Passing Skills on Youth Soccer Players
The aim of this study is to examine the effect of futsal balls on the passing and dribbling skills of 11-12 year old of soccer players. For this purpose, 48 male students whom regularly went to soccer school participated...
Contest coefficients of the elite judo athletes of Russia and Kyrgyzstan (less than 60 kg, 66 kg, 73 kg and 81 kg) from 2010 till 2015
Study aim. The specialists note that the latest changes in the rules of judo have a negative impact on the quality of competition between the athletes representing the Russian Federation and the CIS countries. In connect...
The performance analysis of Islamic republic of Iran broadcasting (IRIB) in comparison with foreign selected channels in the field of sports
The purpose of this study was to analyze the performance of Islamic republic of Iran broadcasting (IRIB) in comparison with foreign selected channels in the field of sports. The methodology of the present study is descri...
Study of LDH adaptations associated with the development of Speed endurance in basketball players U19
Purpose: The aim of this study was to investigate the effects of 8 weeks regular exercise on (LDH) level enzymes adaptation associated with the specific endurance training program. Methods: Research group consists of tot...