Role of Helicobacter Pylori Infection in the Pathogenesis of Minimal Hepatic Encephalopathy and Effect of its Eradication
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 7
Abstract
Background and purpose Minimal hepatic encephalopathy (MHE) is the mildest form in the spectrum of hepatic encephalopathy (HE); it has no recognizable clinical symptoms but mild cognitive and psychomotor deficits. Neuropsychometric testing is an established methodology for quantifying cognitive impairment in MHE. Ammonia is important in the pathogenesis of MHE and H. pylori are known to produce copious amounts of ammonia, thus, it may contribute to the development of MHE in the presence of liver cirrhosis. The study aimed to detect the prevalence of H. pylori infection in cirrhotic patients with and without MHE and to establish the correlation between the presence of H. pylori infection and blood ammonia level and the results of neuropsychometric tests in these cases. Moreover, to investigate the effect of H. pylori eradication on different measured parameters. Material and Methods 80 patients with HCV related liver cirrhosis were included in the study; patients were divided according to the presence or absence of MHE and H. pylori infection into 4 subgroups. Full history taking, routine laboratory investigations, fasting blood ammonia level and detection of H. pylori antigen in stool were done to all studied patients. Also, neuropsychometric tests were performed for diagnosis of MHE. Results and conclusion H. pylori infection is common among cirrhotic Egyptian patients and its role in the pathogenesis of MHE and ammonia production was proved. Screening of cirrhotic patients for detection and eradication of H. pylori is beneficial in the improvement and cure of MHE for better quality of life
Authors and Affiliations
Perihan El Sayed Salem
Keywords
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