Role of host and viral factors and genetic variation of IL28B on therapy outcome in patients with chronic hepatitis C genotype 1b from Serbia
Journal Title: Genetics & Applications - Year 2019, Vol 3, Issue 1
Abstract
Viral and host factors in hepatitis C virus (HCV) infection can influence on therapy outcome to pegylated interferon/ribavirin (PEG-IFN/RBV) and progression of liver fibrosis. Although novel direct-acting antivirals (DAAs) represent promising successful treatment of hepatitis C infection, the majority of patients are deprived of this therapy because of its expensiveness and therefore they remain untreated. Also, the efficacy of this novel treatment may be affected by the presence of resistance-associated substitutions (RASs). This study was designed to describe associations between baseline host and viral factors, progression of liver fibrosis and response to therapy with pegylated interferon/ribavirin (PEG-IFN/RBV) in patients with chronic hepatitis C (HCV) genotype 1b. Pre-treatment of 100 patients with chronic hepatitis C genotype 1b was analyzed, and related to outcome of therapy. TaqMan assay was used to determine SNP rs12979860 in all patients. In our study there was significant correlation between age and response to therapy. Also, we found associations between a known route of transmission and age, gender, stage of liver fibrosis and therapy outcome. With respect to SNP rs12979860, the frequency of the CC genotype in the group with a sustained virologic response (SVR) was significantly higher than in the group of non-responders (NR). In contrast, there was no correlation between IL28B polymorphism and progression of liver fibrosis.
Authors and Affiliations
Snežana Jovanović-Ćupić, Nina Petrović, Milena Krajnović, Maja Bundalo, Nikola Kokanov, Ana Božović, Gorana Stamenković
Keywords
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- EP ID EP592353
- DOI 10.31383/ga.vol3iss1pp36-41
- Views 130
- Downloads 0
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