ROLE OF HYPERBARIC OXYGEN IN NEO-OSTEOGENESIS IN FRACTURES OF LONG BONES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2019, Vol 8, Issue 11
Abstract
BACKGROUND Hyperbaric Oxygen Therapy (HBOT) has been proved to regenerate and revitalize various tissues of the body. But, the role of HBOT in promoting neo-osteogenesis has been experimented mainly in animals. Clinical evidence to support or negate its effectiveness in humans for neo-osteogenesis is lacking due to non-availability of good quality trials. We wanted to assess the role of hyperbaric oxygen in neo-osteogenesis of the fractures of long bones. MATERIALS AND METHODS A randomised control trial was conducted in the Department of Orthopaedics in Indian Naval Hospital Ship Asvini from July 2006 to Mar. 2009. Patients requiring abundant callus for healing like comminuted fractures of long bones, treated by relative stability, fixation and those requiring bone transport, managed with the Ilizarov ring fixator are included in the study. 70 patients who met the selection criteria were randomly allotted to 2 groups with 35 patients each. Patients treated with no HBOT (n=29) as control group (Group 1) and patients treated with HBOT (n=34) as study group (Group 2) as 6 patients from control group and 1 patient from study group were lost to follow-up. Cases selected for trial were given HBOT with 100% oxygen for 45 minutes in a recompression chamber at 2 ATA for 3 weeks. The assessment of osteogenesis was done clinically, radiologically and sonologically at 3 weeks, 6 weeks, 12 weeks and thereafter 6 weekly, till fracture union. RESULTS At 3 weeks, sonological evidence of neo-osteogenesis was found in 55.9% of study group and 44.8% of control group. A similar result of clinical and early radiological evidence was noticed at 6 weeks of follow up. However, there was no significant difference in the neo-osteogenesis noticed between case and control group in the further follow up. CONCLUSION Our study failed to show any significant clinical evidence to support or refute the effectiveness of HBOT for the union of fractures. A clinical trial with large sample size is needed to define the role of HBOT in fracture healing, if any
Authors and Affiliations
Jiss Joseph Panakkal, Vijoy Kumar Sinha V. S. M
Keywords
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- EP ID EP555607
- DOI 10.14260/jemds/2019/174
- Views 90
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