Role of IL-6 and Insulin Resistance in the Etiopathogenesis of Atherosclerosis

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Role of IL-6 and Insulin Resistance in the Etiopathogenesis of Atherosclerosis

Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 4

Abstract

Objectives: Our study attempts to evaluate the role of Nuclear Factor-kappa Beta(NF-κB), Interleukin-6 and Homeostatic model assessment of insulin resistance (HOMA-IR) in assessment of severity of atherosclerosis currently assessed by angiography. Methods: 50 cases of angiographically significant atherosclerosis (>50% obstruction in coronary arteries) and 50 age, sex, BMI matched patients with insignificant atherosclerosis (<50% obstruction) on angiography were selected from G.B Pant Hospital. Serum IL-6, NF-κB was estimated by ELISA and serum insulin was estimated by CLIA. Results: Serum IL-6, NF-κB, Insulin and HOMA-IR were significantly raised in cases (p=0.003, 0.05, 0.003, 0.012 respectively). Upon correlation analysis, we observed that IL-6 has statistically significant correlation (Pearson’s coefficient, r=0.196 and p=0.04) with NF-κB. Upon binomial logistic regression analysis, NF-κB emerged as the best predictor of severity of atherosclerosis (OD=19.2). Conclusion: Our study shows that atherosclerotic progression is associated with inflammation, insulin sensitivity and endothelial dysfunction. The study also asserts a significant correlation between inflammation and NF-κB, thereby throwing light on critical role of NF-κB in pathways of inflammation promoting atherosclerosis. Further studies in larger sample size are required to assess NF-κB as marker of severity of atherosclerosis.Objectives: Our study attempts to evaluate the role of Nuclear Factor-kappa Beta(NF-κB), Interleukin-6 and Homeostatic model assessment of insulin resistance (HOMA-IR) in assessment of severity of atherosclerosis currently assessed by angiography. Methods: 50 cases of angiographically significant atherosclerosis (>50% obstruction in coronary arteries) and 50 age, sex, BMI matched patients with insignificant atherosclerosis (<50% obstruction) on angiography were selected from G.B Pant Hospital. Serum IL-6, NF-κB was estimated by ELISA and serum insulin was estimated by CLIA. Results: Serum IL-6, NF-κB, Insulin and HOMA-IR were significantly raised in cases (p=0.003, 0.05, 0.003, 0.012 respectively). Upon correlation analysis, we observed that IL-6 has statistically significant correlation (Pearson’s coefficient, r=0.196 and p=0.04) with NF-κB. Upon binomial logistic regression analysis, NF-κB emerged as the best predictor of severity of atherosclerosis (OD=19.2). Conclusion: Our study shows that atherosclerotic progression is associated with inflammation, insulin sensitivity and endothelial dysfunction. The study also asserts a significant correlation between inflammation and NF-κB, thereby throwing light on critical role of NF-κB in pathways of inflammation promoting atherosclerosis. Further studies in larger sample size are required to assess NF-κB as marker of severity of atherosclerosis.

Authors and Affiliations

Arpita Suri, Ritu Singh, Sanjay Tyagi, Jayashree Bhattacharjee

Keywords

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EP ID EP534225
DOI 10.21276/ijmrp.2018.4.4.010
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