ROLE OF LOCOREGIONAL TREATMENT IN THE MANAGEMENT OF METASTATIC BREAST CANCER
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 1
Abstract
BACKGROUND The treatment of metastatic breast cancer depends on the individual patient and receptor status and general condition of the patient. Even with newer systemic and locoregional treatment, metastatic breast cancer cannot be cured completely at present. In few patients with good prognostic factor, these treatment modalities increase the progression-free survival which in turn may significantly affect the overall survival. Many patients with metastases may live several years with modern locoregional treatment and systemic chemotherapy. The aim of the treatment of metastatic breast cancer should be towards increasing the symptom-free survival and quality of life. At the same time the side effects of the treatment should be minimised. The objective of the study is to evaluate the role of locoregional treatment such as local radiotherapy and surgery in the management of patients with metastatic breast cancer. MATERIALS AND METHODS This is a retrospective observational study. One hundred and Ninety-five patients with metastatic breast cancer between the years 2003 to 2008 were taken for this retrospective ongoing study. Among these, seventy-five patients did not receive locoregional treatment, and the remaining one hundred and twenty patients received locoregional treatment to the primary. Locoregional treatment included radiotherapy and surgery. RESULTS Patient’s survival was analysed at the end of 1 year, 3 years, 5 years, and at the end of 10 years. It was found that, in patients receiving concurrent chemoirradiation, survival rates at the end of 1, 3, 5 and 10 years were 89%, 58%, 46% and 42% respectively. Similarly, in patients receiving concurrent chemoirradiation followed by surgery, survival was 97%, 80%, 71% and 70% respectively. Further, survival for chemotherapy was 60%, 5%, 2% and 0% respectively. Again, for the arm including only radiotherapy, survival was around 67%, 33%, 33% and 33% respectively. Those patients who receive only hormonal therapy had 50%, 13%, 13% and 13% overall survival at the end of 1, 3, 5 and 10 years. CONCLUSION The data reported in this retrospective study confirmed that chemoirradiation improved overall survival and symptomatic local control, demonstrated in locoregionally treated patients with metastatic breast cancer.
Authors and Affiliations
Sivagnanam Balaji, Sam Deva Kumar J, Selvaluxmy G
Keywords
Related Articles
- EP ID EP284496
- DOI 10.14260/jemds/2018/18
- Views 100
- Downloads 0
MRI EVALUATION OF TRAUMATIC KNEE JOINT
BACKGROUND MRI is a non-invasive technique for assessing internal ligaments and menisci of knee. MRI provides excellent soft tissue contrast and is an accurate technique for examination of the soft tissue and osseous str...
HYPOKALAEMIA IN ORGANOPHOSPHOROUS COMPOUND POISONING
BACKGROUND Inhibition of cholinesterase plays a key role in organophosphate (OP) toxicity. There are other factors which contribute to the severity of poisoning. One of them is electrolyte imbalances such as hypokalaemia...
A STUDY OF DISTRIBUTION OF ABO AND RH BLOOD GROUPS SYSTEM AMONG BLOOD DONORS AT A TERTIARY CARE HOSPITAL
Up till now about 400red cells antigen have been identified. The majority are inherited by Mendelian fashion. The ABO and Rh blood group system was first to be identified and is most important for blood transfus...
A STUDY OF HAEMATOLOGICAL MANIFESTATIONS IN HIV POSITIVE PATIENTS- CORRELATION WITH CD4 COUNT
BACKGROUND HIV infection is a multisystem disease and haematological abnormalities are among the most common complications of HIV. HIV associated haematological abnormalities seem to be dependent on the level of virus re...
LABOUR ANALGESIA- A COMPARISON OF EPIDURAL BOLUS ADMINISTRATION OF 0.0625% BUPIVACAINE WITH 0.0002% FENTANYL VERSUS 0.125% PLAIN BUPIVACAINE
BACKGROUND Labour is an extremely painful process. Labour pain is of major concern since most parturients experience significant pain of extremely severe intensity. Labour pain can have deleterious effects on the mother,...