Role of Magnetic Resonance Spectroscopy in Early Detection of Alzheimer’s Disease
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
Aims and Objectives: To assess the role of magnetic resonance spectroscopy in diagnosing early manifestations of Alzheimer’s disease and to improve its accuracy in diagnosis of neurodegenerative diseases. Materials and Methods: The study was conducted in a group of 60 patients, who underwent MRI, along with MR spectroscopy, at our hospital. The study group was divided into thirty cognitively impaired and thirty cognitively normal patients, based on their clinical symptoms. MR spectroscopy was performed in posterior cingulate gyrus region using single voxel technique and the metabolite ratios NAA/Cr, Cho/Cr, mI/Cr and NAA/mI were calculated. These ratios were correlated with imaging and clinical diagnosis. Receiver Operating Characteristics (ROC) analysis was performed to obtain cut off values with appropriate sensitivity and specificity. Results: Among sixty patients, 38 (63.3%) male and 22 (36.7%) female subjects in the age group of 35 to 85 years were enrolled in this study. MRS showed that NAA/Cr and NAA/mIratios were significantly reduced (NAA/Cr: p value < 0.001, sensitivity 86.7%, specificity 70%; NAA/mI: p value < 0.001, sensitivity 83.3%, specificity 65.5%). The ROC analysis revealed estimated cut off values of NAA/Cr <1.635 and NAA/mI<3.720 and we proposed that these values have an acceptable sensitivity and specificity in predicting the natural outcome of the disease process. Conclusion: Magnetic resonance spectroscopy can be used as a screening tool in neuroimaging of neurodegenerative diseases and can be considered as a possible adjunctive screening marker of preclinical Alzheimer’s disease in clinical practice.
Authors and Affiliations
Dr. Jini Abraham, Dr. Bharath Kumar Shetty, Dr. Meera Varghese, Dr. Ramzi S. , Dr. Prasad Hegde, Dr. Ganesh K.
Keywords
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- EP ID EP572128
- DOI 10.9790/0853-1804028490.
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