Role of Magnetic Resonance Spectroscopy in Early Detection of Alzheimer’s Disease
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 4
Abstract
Aims and Objectives: To assess the role of magnetic resonance spectroscopy in diagnosing early manifestations of Alzheimer’s disease and to improve its accuracy in diagnosis of neurodegenerative diseases. Materials and Methods: The study was conducted in a group of 60 patients, who underwent MRI, along with MR spectroscopy, at our hospital. The study group was divided into thirty cognitively impaired and thirty cognitively normal patients, based on their clinical symptoms. MR spectroscopy was performed in posterior cingulate gyrus region using single voxel technique and the metabolite ratios NAA/Cr, Cho/Cr, mI/Cr and NAA/mI were calculated. These ratios were correlated with imaging and clinical diagnosis. Receiver Operating Characteristics (ROC) analysis was performed to obtain cut off values with appropriate sensitivity and specificity. Results: Among sixty patients, 38 (63.3%) male and 22 (36.7%) female subjects in the age group of 35 to 85 years were enrolled in this study. MRS showed that NAA/Cr and NAA/mIratios were significantly reduced (NAA/Cr: p value < 0.001, sensitivity 86.7%, specificity 70%; NAA/mI: p value < 0.001, sensitivity 83.3%, specificity 65.5%). The ROC analysis revealed estimated cut off values of NAA/Cr <1.635 and NAA/mI<3.720 and we proposed that these values have an acceptable sensitivity and specificity in predicting the natural outcome of the disease process. Conclusion: Magnetic resonance spectroscopy can be used as a screening tool in neuroimaging of neurodegenerative diseases and can be considered as a possible adjunctive screening marker of preclinical Alzheimer’s disease in clinical practice.
Authors and Affiliations
Dr. Jini Abraham, Dr. Bharath Kumar Shetty, Dr. Meera Varghese, Dr. Ramzi S. , Dr. Prasad Hegde, Dr. Ganesh K.
Keywords
Related Articles
- EP ID EP572128
- DOI 10.9790/0853-1804028490.
- Views 53
- Downloads 0
Medical Abortion in Early Pregnancy By oral Mifepristone And oral Misoprostol
This study was conducted to observe the efficacy of medical abortion using mifepristone 200 mg and misoprostol 800 mg by oral route in pregnant women with amenorrhoea of up to 63 days. Methods: 60 women were divided into...
Premorbid Social functioning in Schizophrenia, Bipolar Affective disorder and Healthy Controls – A Comparative Study
Objective of the study was to compare the premorbid social adjustment in patients with schizophrenia, bipolar affective disorder and healthy controls. Method: Maternal recall was used to assess the premorbid adjustment o...
Study of effect of Age on Retinal Nerve Fibre Layer Thickness and Optic Nerve Head Parameters in Healthy Individuals Using Sd-Oct
.
Prevalence of Metabolic Syndrome in Patients with Psoriasis
Background: Psoriasis is a chronic inflammatory disease of the skin and is associated with an increased risk of cardiovascular atherosclerosis. Metabolic syndrome, a conglomerate of various clinical and biochemical param...
Magnetic Resonance Imaging in Carcinoma of Cervix
Cervical carcinoma is the third most common gynecological malignancy ( after endometrial and ovarian carcinoma ) and is typically seen in younger women , often with serious consequences. MR imaging has become essential i...