Role of Mast Cells in Appendicitis
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 5
Abstract
Aim and objective- 1) To identify and quantify the mast cells in surgically resected inflamed appendices. 2) To assess the role of mast cells in the pathogenesis of acute appendicitis. 3) To evaluate the extent of mast cell involvement in appendicitis Introduction- Acute appendicitis is a common surgical emergency. Appendix continues to be the major chunk of surgical specimens received in Pathology laboratory. However, pathogenesis of appendicitis remains poorly understood. Mast cells play an important role in various inflammatory and immune reactions. Mast cells could be one of the important cell populations responsible for nerve proliferation and hypertrophy in cases with clinically and histopathologically diagnosed appendicitis. Materials and Methods- One fifty appendicitis cases were analyzed with routine hematoxylin and eosine staining and other special stains like toluidine blue. The number of mast cells present in ten consecutive high power field was counted by randomly in all the sections with one percent toluidine blue and graded the mast cells. Results: Among one fifty cases , the acute appendicitis were fifty five cases (55), with higher mast cell count, acute eosinophilic appendicitis cases were eleven (11) and chronic appendicitis were eighty four cases(84), with highest mast cell count. Conclusion: We concluded that mast cell count was higher in acute appendicitis indicating immunological and non immunological injury and was highest in chronic appendicitis, indicating growth interaction between mast cells, nerves and fibrosis. Our observations support the allergic theory of appendicitis rather than the obstructive theory.
Authors and Affiliations
Dr. Jyoti Sharma
Keywords
Related Articles
- EP ID EP369724
- DOI -
- Views 54
- Downloads 0
Aesthetic Rehabilitation of Non-Vital Teeth
Discolored and non-vital teeth result in aesthetic problems especially in anterior teeth owing to being easily noticed. In order to bleach the coloration occurring in teeth which canal treatment applied, sodium perborate...
Comparative Study of Pressor Responses after Tracheal Extubation and LMA (Laryngeal Mask Airway) Removal in Controlled Hypertensive Patients: A Randomised Clinical Trial
Background and objectives: Airway management using endotracheal intubation and laryngeal mask airway (LMA) are known to induce hemodynamic changes. The predominant response is tachycardia and systemic hypertension. The p...
Evaluation of Two Phenotypic Methods for the Confirmatory Testing of Extended Spectrum Beta Lactamases Producing Strains of Klebsiella Pneumoniae
Background: The resistance to antimicrobials has become a serious global health concern with negative consequences on treatment strategies and increasing health-care costs. The extended spectrum beta lactamases producing...
Risk-Taking Behaviour among Commercial Motorcycle Taxi [Okada] Riders in a Semi-Rural Area of Bayelsa State
Background: Commercial motorcycle taxis [Okada] have become an increasingly important mode of transportation in most Nigerian towns and villages due to the lack of proper road infrastructure and poor state of transportat...
Association of Blood Pressure and Biochemical Parameters with Adiposity in Women
Modifications in lifestyle have an impact on the incidence of metabolic disorders such as the development of type 2 diabetes, dyslipidemias and metabolic syndrome (MS) that aggravate the risk of developing cardiovascular...