Role of Mast Cells in Appendicitis
Journal Title: International Journal of Health Sciences and Research - Year 2017, Vol 7, Issue 5
Abstract
Aim and objective- 1) To identify and quantify the mast cells in surgically resected inflamed appendices. 2) To assess the role of mast cells in the pathogenesis of acute appendicitis. 3) To evaluate the extent of mast cell involvement in appendicitis Introduction- Acute appendicitis is a common surgical emergency. Appendix continues to be the major chunk of surgical specimens received in Pathology laboratory. However, pathogenesis of appendicitis remains poorly understood. Mast cells play an important role in various inflammatory and immune reactions. Mast cells could be one of the important cell populations responsible for nerve proliferation and hypertrophy in cases with clinically and histopathologically diagnosed appendicitis. Materials and Methods- One fifty appendicitis cases were analyzed with routine hematoxylin and eosine staining and other special stains like toluidine blue. The number of mast cells present in ten consecutive high power field was counted by randomly in all the sections with one percent toluidine blue and graded the mast cells. Results: Among one fifty cases , the acute appendicitis were fifty five cases (55), with higher mast cell count, acute eosinophilic appendicitis cases were eleven (11) and chronic appendicitis were eighty four cases(84), with highest mast cell count. Conclusion: We concluded that mast cell count was higher in acute appendicitis indicating immunological and non immunological injury and was highest in chronic appendicitis, indicating growth interaction between mast cells, nerves and fibrosis. Our observations support the allergic theory of appendicitis rather than the obstructive theory.
Authors and Affiliations
Dr. Jyoti Sharma
Keywords
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