ROLE OF MDA, VITAMIN E AND VITAMIN C IN PREGNANCY INDUCED HYPERTENSION - A CLINICAL STUDY
Journal Title: Journal of Advanced Medical and Dental Sciences Research - Year 2017, Vol 5, Issue 3
Abstract
Background: Hypertension is the leading causes of maternal and perinatal deaths in developing countries. Hypertension prevalence in pregnancy varies from 5% -10% and it affects 20% - 30% of the adult population. The present study was conducted to assess the level of MDA, vit E and vit C in pregnancy and their effect in development of pregnancy induced hypertension. Materials & Methods: Study included 40 pregnant women in age range from 18- 30 years. Primigrividae with blood pressure >140/90mm of Hg with odema and proteinuria within 28-42 weeks were included. After obtaining written consent, they were divided into 2 groups- 1. Primi with mild preeclampsia with B.P. > 140/90- 150/109 mm Hg and urinary protein > 0.3 gm/day. 2. Primi with severe preeclampsia with B.P. > 160/ 100 mm Hg and urinary protein > 3 gm/ day. An aged matched control group with B.P <140/100mm Hg with no odema and proteinuria was included in the study. In all subjects, serum malondialdehyde level (MDA), serum vitamin E level, plasma vitamin C level and urinary protein estimation was performed. Results: 40 subjects had normal prima gravida, 28 had primi with mild preeclampsia and 12 had primi with severe pre eclampsia. The difference was significant (P-0.02). Mean age in normal prima gravid was 24 years, in primi with mild preeclampsia was 25.32 and primi with severe pre eclampsia was 26.45. Systolic blood pressure was 148.2 mm Hg and 166.4 mm Hg in primi with mild preeclampsia and primi with severe pre eclampsia respectively. Distolic blood pressure was 98 mm Hg and 114. 6 mm Hg in primi with mild preeclampsia and primi with severe pre eclampsia respectively. Mean priteinuria was 0.92 gm/day and 3.2 in with mild preeclampsia and primi with severe pre eclampsia respectively. Odema was + and ++ in with mild preeclampsia and primi with severe pre eclampsia respectively. Mean MDA was 2.44, 4.88 and 5.64 in normal prima gravida, primi with mild preeclampsia and primi with severe pre eclampsia respectively. Vitamin E level was 8.25, 7.14 and 7.62 in normal prima gravida, primi with mild preeclampsia and primi with severe pre eclampsia respectively. Plasma vitamin C level was 8.26, 6.8 and 6.9 in normal prima gravida, primi with mild preeclampsia and primi with severe pre eclampsia respectively. The difference was significant (P < 0.05). Conclusion: There is imbalance between antioxidant vitamin status and lipid peroxidation. Lipid peroxidation is one of the initiating factor in preeclampsia.
Authors and Affiliations
Sweta Kumari, Beena Singh
Keywords
Related Articles
- EP ID EP557791
- DOI -
- Views 104
- Downloads 0
Attitude and Knowledge of Mothers Regarding Oral Hygiene Status of School Children
Background: Parents’ attitudes have a positive impact on the state of children’s oral health. The present study was conducted to determine attitude and knowledge of mothers regarding oral hygeine status of school childre...
Evaluation of Two Different Treatment Modalities for the Management of Oral Submucous Fibrosis: A Relative Report and Analysis
Background: Oral submucous fibrosis is a perpetual dynamic ailment of the oral cavity with capability of threatening malignancy formation. For the treatment of this pathologic condition, an extensive variety of modalitie...
Comparative Efficacy of Chlorhexidine and Herbal Mouth Rinse in Patients with gingivitis
Background: Mouthwashes (mouthrinses) are fluids used to flush the mouth for various purposes: to evacuate micro-organisms, to go about as an astringent, to aerate and to have a helpful impact by easing contamination or...
Association of Body Mass Index and the Risk of Oral Submucous Fibrosis in Maharashtra, India
Background: Oral submucous fibrosis is an oral premalignant condition which is irreversible. This condition generally presents as restricted mouth opening due to formation of fibrous bands, stiffening of the tongue, alte...
To Establish the Relation of Fasting Blood Glucose Level in Patients with Gall Stones- A Clinical Study
Background: Gallbladder (GB) stone disease is a common disorder of the adult population in western countries. GB stone formation is multi factorial. The present study was conducted to assess the role of fasting blood glu...