Role of MicroRNAs in Progression and Recurrence of Early-Stage Lung Adenocarcinoma
Journal Title: Pulmonary Research and Respiratory Medicine – Open Journal - Year 2015, Vol 2, Issue 1
Abstract
Lung cancer is the leading cause of cancer-related death worldwide, and the majority of cases (77%) are not diagnosed until the disease has spread to regional lymph nodes or distant sites. Even among Non-Small Cell Lung Cancer (NSCLC) adenocarcinoma patients who have been diagnosed early and where there has been no spread to lymph nodes, recurrence after surgical intervention is high. Improved understanding of the molecular alterations involved in aggressivity and recurrence of these tumors may provide better biomarkers for the identification of patients who would benefit from adjuvant chemotherapy. By comparing the expression of microRNAs in advanced Stage II/III tumors with those expressed in earlier Stage I tumors, we aimed to identify differentially expressed molecular biomarkers that could underly progression and recurrence of Stage I tumors. This pilot study utilized TaqMan qPCR assays to assess the expression of microRNAs in tumor tissue, matched normal tissue and plasma samples from Stage I and Stage II/III lung adenocarcinoma patients. Seven microRNAs were identified from plasma that could distinguish between patients with Stage I and Stage II/III adenocarcinoma. The up-regulation of miR-29a in plasma of patients with later-stage adenocarcinoma would result in enhanced expression of several molecules involved in integrin signaling, migration and proliferation. Analysis of differential expression of microRNAs in later-stage compared to early-stage lung adenocarcinoma implicates focal adhesion and ECM-receptor pathways in progression and recurrence. Plasma miR-29a is a promising biomarker that can be assessed non-invasively and whose clinical utility should be pursued.
Authors and Affiliations
Susan E. Douglas
Keywords
Related Articles
- EP ID EP550067
- DOI 10.17140/PRRMOJ-2-108
- Views 131
- Downloads 0
Diagnosis of Pulmonary and Extra Pulmonary Tuberculosis: How Best is CBNAAT when Compared to Conventional Methods of TB Detection?
Background Globally, India is a home for more than 25% of global Tuberculosis (TB) burden. The sensitivity of smear microscopy and its inability to detect drug resistance limits its impact on TB control. We compared the...
Measurement of Activities of Daily Living in Patients with Chronic Obstructive Pulmonary Disease
Chronic obstructive pulmonary disease (COPD) is a heterogeneous inflammatory lung disease characterized by progressive airway obstruction, which results in exertional dyspnea and physical disability. It is the third lead...
Cheyne-Stokes Respiration Revisited: Clinical Clue to the Diagnosis for Acute Exacerbation of Congestive Heart Failure
A 72-year-old man was admitted to the hospital to initiate chemotherapy for pleomorphic lung carcinoma (T4N0M1a, stage 4 cancer). He had a history of chronic systolic heart failure with severe mitral regurgitation diagno...
Rehabilitation in Patients Undergoing Lung Transplantation (LTx)
Lung transplantation (LTx) has become an established therapeutic option for treating patients with end-stage pulmonary disease. Before and after LTx, physical ability might be restricted due to certain effects on respira...
A Review of Non-Pharmacological Pulmonary Rehabilitation for Patients Receiving Palliative Care
Introduction: Dyspnea is common in patients experiencing chronic and malignant lung conditions. It is a very distressing symptom that often results in anxiety and depression. Pulmonary rehabilitation together with pallia...