ROLE OF MONOCLONAL ANTIBODIES IN CLINICAL RESEARCH AND THERAPY- A REVIEW
Journal Title: World Journal of Pharmaceutical and life sciences - Year 2017, Vol 3, Issue 3
Abstract
Antibodies are natural proteins with modular structure, specific pharmacodynamics and pharmacokinetics and possibly produced against any antigens, thus giving them several advantages over small drug therapeutics. Monoclonal antibodies (mAb) have been applied to the diagnosis and therapy of an array of human diseases. They are a novel and promising therapeutic class used with great results in inflammatory diseases such as rheumatoid arthritis. The initial failures of early clinical trials have been overcome through the production of a new generation of mAb which features reduced immunogenicity and improved targeting abilities. The early models of mAb therapy were focused on enhancing the cytolytic mechanisms against the tumor cells. More recently, successful mAb-based therapies were targeted to molecules involved in the regulation of growth of cancer cells. Despite all the difficulties, clinical data is outlining an increasingly significant role for antibody-mediated cancer therapy as a versatile and powerful instrument in cancer treatment. Lung cancer is the leading cause of cancer-related deaths in industrialized countries and non small cell lung cancer (NSCLC) accounts for 85% of all lung cancers. It seems that mAbs therapy in NSCLC clearly marks the start of a new era in NSCLC treatment, with promise in improving patient survival and quality of life. Monoclonal antibodies (MAbs) are an old immunological tool with applications in the fields of immunology, biotechnology, biochemistry, and applied biology. Recently, MAbs have been widely applied in the field of clinical medicine. Currently, MAbs account for one-third of all the new therapeutic treatments for breast cancer, leukemia, arthritis, transplant rejection, asthma, and psoriasis, with many more late-stage clinical trials being conducted. In this review, we outline the (i) production of MAbs, (ii) application of MAbs, (iii) antibody engineering, and (iv) pharmaceutical application of MAbs.
Authors and Affiliations
Nithin Manohar
Keywords
Related Articles
- EP ID EP648990
- DOI -
- Views 191
- Downloads 0
REGULATION OF BREASTFEEDING PATTERNS BY POSTNATAL MOTHERS
Maternal attitudes toward breastfeeding have impact on when they commence and how long they practice breastfeeding. This study examined how postnatal mothers regulate their breastfeeding patterns. Convenient sampling met...
MICROBIOLOGICAL APPROACH AND PHYSIOCHEMICAL ANALYSIS OF PESTICIDES POLLUTED SOIL FROM CUDDALORE DISTRICT
Microbes are an important group of organisms and they thrive in wide variety of soil habitats. In modern agricultural practices variety of synthetic chemical compounds including pesticides, e.g., zoocides, fungicides, he...
A CLINICAL STUDY ON THE ROLE OF GANDHAK MALAHAR IN THE MANAGEMENT OF (CHARAKOKTA & SUSHRUTOKTA) TYPE 1 DADRU & TYPE 2 DADRU KUSHTA
Skin diseases are common manifestation in present era and more so frequent in the elder age. The patients of skin disease are additionally prone to experience physical, emotional & socio-economic embarrassment in the soc...
ONCOGENICITY OF TOBACCO-SMOKING: A REVIEW ON SQUAMOUS CELL CARCINOMA OF THE TONGUE, DIAGNOSIS AND TREATMENT
Squamous cell carcinoma (SCC) of the tongue is the commonest type of tongue cancer affecting young smokers and older men (over 45 years of age) than women. It represents more than ninety percent of all head and neck canc...
REVIEW ON UVA-URSI- A MIRACLE HERB FOR URINARY TRACT DISORDERS
The traditional Indian system of medicines like Ayurveda mainly uses medicinal plants for the management of diseases. Ayurveda provides holistic treatment combating physical as well as mental illnesses. As herbal product...