ROLE OF NARINGIN ONGEMCITABINE-INDUCED LIPID PEROXIDATION
Journal Title: Journal of Pharmaceutical and Scientific Innovation - Year 2018, Vol 7, Issue 3
Abstract
Aim: The aim of the present study was to investigate the antiperoxidative property of naringin on gemcitabine-induced lipid peroxidation. Methods: The in vitrowork was carried out usinggoat liver as model lipid source. Two common laboratory markers such as malondialdehyde and reduced glutathione were used for the model. Results: The data generated from the work showed that gemcitabine increase the MDA level and reduce the GSH level. But when gemcitabine was used in combination with naringin then there is decrease in MDA level and increase in GSH level.Conclusion: The results showed thatgemcitabine has the ability to induce lipid peroxidation to a significant extent and it was also found that naringin has antiperoxidative potential to suppress the gemcitabine-induced toxicity.
Authors and Affiliations
Sarbani Dey Ray
Keywords
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- EP ID EP631016
- DOI 10.7897/2277-4572.07385
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