Role of nitric oxide in liver regeneration
Journal Title: Annals of Hepatology - Year 2012, Vol 11, Issue 5
Abstract
The liver has a remarkable ability to regenerate in response to surgical removal or chemical insult. The mechanisms regulating regenerative processes are complex, and incompletely understood. A large number genes, which are not normally expressed in the quiescent liver, are activated. Immediately after partial hepatectomy (PH) (1-6 h), nitric oxide (NO) is synthesized by liver parenchymal and nonparenchymal cellsfrom L-arginine, via induction of the inducible form of nitric oxide synthase (iNOS). NO is a highly reactive molecule, known to be involved in diverse biological processes in nearly all aspects of life. Liver regeneration is a major area within the field of NO research. Our review describes several processes that havebeen suggested to be modulated by the NO released following PH, including proliferation, apoptosis and angiogenesis in the remnant tissue. Because iNOS up regulation has such profound physiologic effects, its regulation is strictly controlled. The up regulation of iNOS after PH and the subsequent production of NOinduce positive effects on the regulation of early stages of the regenerative process. However, overproduction (> 100%) can have detrimental effects, including apoptosis. Thus, the iNOS induction after PH is necessary, and enough to allow for the normal regenerative process.
Authors and Affiliations
Cristina Carnovale, Maria Ronco
Keywords
Related Articles
- EP ID EP78184
- DOI -
- Views 123
- Downloads 0
Mucinous Cystic Neoplasm of the Liver or Intraductal Papillary Mucinous Neoplasm of the Bile Duct? A Case Report and a Review of Literature
Mucinous cystic neoplasm of the liver (MCN-L) and intraductal papillary mucinous neoplasm of the bile duct (IPMN-B) are diagnoses that were classified by the World Health Organization in 2010 as mucin-producing bile duct...
Association Between Hepatitis C Virus and Chronic Kidney Disease: A Systematic Review and Meta-Analysis
Introduction. The role of hepatitis C virus infection as a risk factor for the development and progression of chronic kidney disease in the general population remains unclear. Material and methods. A systematic review of...
Thymosin β10 as a predictive biomarker of response to 5-fluorouracil chemotherapy in cholangiocarcinoma
Introduction and aim. 5-Fluorouracil (5-FU) is the most commonly used chemotherapeutic drug in the treatment of cholangiocarcinoma (CCA). Since development of drug resistance to 5-FU in CCA patients is the primary cause...
Colorectal cancer surveillance in primary sclerosing cholangitis and inflammatory bowel disease
Tumor necrosis alpha serum levels parallels isolated hypertransaminasemia in the third trimester of pregnancy