ROLE OF NON-HIGH-DENSITY LIPOPROTEIN CHOLESTEROL IN CEREBROVASCULAR ACCIDENTS
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2019, Vol 6, Issue 33
Abstract
BACKGROUND The role of non-high-density cholesterol (non-HDL-C) in cardiovascular events and cerebrovascular events remains a subject of controversy. We wanted to evaluate the role of non-HDL-C in stroke. METHODS Our cross-sectional study enrolled 100 participants with acute cerebrovascular accident (CVA) excluding traumatic CVA and CVA due to vasculitis. Institutional ethics committee approved the study and written informed consent was obtained from all study participants. Collected data included history, socio demographic parameters, examination findings and laboratory parameters. Non-HDL-C was calculated by deducting HDL-C from TC. Tests of significance were independent sample t test and Chi square test and a p <0.05 was considered statistically significant. RESULTS The mean age of stroke was ~64 years, mean systolic and diastolic blood pressure were in the prehypertensive range. Significant association of serum LDL and non-HDL with ASCVD risk categorization was observed. CONCLUSIONS Increase in incidence of stroke among young was observed with higher prevalence among males. Increasing burden of prehypertension and diabetes mellitus was observed among stroke patients. 20% participants had high serum non-HDL with normal serum LDL and 18% participants had high serum non-HDL with normal serum total cholesterol. Our study demonstrates the significance of non-HDL in acute stroke and might be a better predictor when used along with conventional investigations. Further studies on larger samples are required to demonstrate the usefulness of this parameter for predicting cerebrovascular accidents.
Authors and Affiliations
Sechassayana N. , Doraickannu T, Jomi James
Keywords
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- EP ID EP670451
- DOI 10.18410/jebmh/2019/452
- Views 80
- Downloads 0
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