Role of ondansetron in decreasing vomiting and duration of hospitalization in children aged 6 months to 14 years
Journal Title: Electronic Physician - Year 2010, Vol 2, Issue 2
Abstract
Background: Treatment of vomiting in acute gastroenteritis can increase the rate of successful oral rehydration therapy (ORT) and lower the need for intravenous fluid administration. The aim of this study was to investigate the role of ondansetron in decreasing vomiting and duration of hospitalization in 6 month to 14 year old children. Methods: In 2010, a double blind randomized controlled trial was carried out based on 100 children between six months and 14 years old with acute gastroenteritis and vomiting. Each child satisfied the inclusion criteria and agreed to participate in the study after receiving a complete explanation about the study. Participants were randomly divided into two groups to either receive intravenous ondansetron (single dose of 0.15mg/kg) or an intravenous placebo (5% dextrose water). The duration of hospitalization and number of vomiting episodes were compared between the two groups 4 hours after treatment. Data were analyzed using SPSS16 software. Results: Duration of hospitalization was 38.30±18.62 hours in those receiving ondansetron and 45.10±25.79 hours in the control group. There was no statistically significant difference between the two groups (P=0.352). The number of vomiting episodes was 0.06±0.23 in the ondansetron group and 0.58±0.90 in the control group. This difference is statistically significant (P=0.000). No adverse effects were seen in either group relating to the drug. Conclusions: This study demonstrated that intravenous ondansetron can effectively reduce the frequency of vomiting associated with acute gastroenteritis. We recommend administration of ondansetron for management of children with acute gastroenteritis but further studies with a larger sample size would be beneficial.
Authors and Affiliations
Asad Setayesh, Farhad Ghahramani, Saeed Teshnize, Hamidreza Mahboobi, Keramat Allah Jahanshahi, Elizabeth Cottrell
Keywords
Related Articles
- EP ID EP113359
- DOI -
- Views 126
- Downloads 0
Probiotic for irritable bowel syndrome in pediatric patients: a randomized controlled clinical trial.
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder in children. Recently, probiotics have been suggested as a treatment option for gastrointestinal disorders. The most effective species and the most app...
Effect of Consultation and Educating in Preparation Classes for Delivery on Pregnancy Consequences: A Randomized Controlled Clinical Trial
BACKGROUND: Care during pregnancy and performing consultation for delivery preparation play an important role in improving pregnant women's knowledge. OBJECTIVE: The purpose of this study was to investigate the effect o...
Cost-Effectiveness of Zoledronic Acid to Prevent and Treat Postmenopausal Osteoporosis in Comparison with Routine Medical Treatment
INTRODUCTION: Fractures caused by osteoporosis are prevalent among elderly females, which reduce quality of life significantly. This study aimed at comparing cost-effectiveness of Zoledronic acid in preventing and treati...
Canaloplasty versus Viscocanalostomy in Primary Open Angle Glaucoma
INTRODUCTION: The purpose of this study was to compare the efficacy and safety of canaloplasty versus viscocanalostomy in management of uncontrolled primary open angle glaucoma (POAG) with medication. METHODS: Canalopla...
Efficacy of combination of Viola odorata, Rosa damascena and Coriandrum sativum in prevention of migraine attacks: a randomized, double blind, placebo-controlled clinical trial
BACKGROUND: Migraine is the second most common type of headache after tension headaches. In Iranian traditional medicine several herbal drugs are used for the treatment of headache. Including, a product of Iranian tradit...