Role of Ormeloxifene in the Treatment of Dysfunctional Uterine Bleeding.
Journal Title: IJAR-Indian Journal of Applied Research - Year 2016, Vol 6, Issue 10
Abstract
Introduction: Dysfunctional uterine bleeding (DUB) is a state of abnormal uterine bleeding without any clinically detectable organic, systemic and iatrogenic cause. It is the most common menstrual disorder of women in reproductive age and is a diagnosis of exclusion. Aims and Objectives: The aim of the present study is to evaluate the efficiency and safety of Ormeloxifene in Dysfunctional Uterine bleeding. Method: This prospective study was conducted in the Dept of Obstretics and Gynaecology JLNMCH, Bhagalpur over a period of 1 year from Jan 2015 to Dec 2015. The Diagnosis of Dysfunctional Uterine bleeding was grade after excluding possible causes of abnormal uterine bleeding. 50 patients of DUB were recruited from OPD. Two pre treatment cycles were compared with six consecutive treatment cycles of Ormeloxifene. All cases were given Ormeloxifene twice a week for 3 months then once a week for another 3 months. Follow up was done at 3 months and 6 months. Main outcome measures were menstrual blood loss. Result: Almost all patients had PBAC score less than 100, thus no menorrhagia following treatment. 11 patients developed amenorrhoea which is the most common side effect of Ormeloxifene. 82% of patients had decrease in endometrial thickness by more than 0.5 mm. Almost all patients had increase in haemoglobin level following treatment. Side effects seen during treatment were G.I side effects, headache, Amenorrhoea. Conclusion: Ormeloxifene is well tolerated and safe alternative for medical management of Dysfunctional uterine bleeding.
Authors and Affiliations
Geeta Rani, Dr Anupama Sinha, Dr Bindu Sinha
Keywords
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