Role of Pentoxifylline in Severe Alcoholic Hepatitis
Journal Title: Journal of Medical Science And clinical Research - Year 2016, Vol 4, Issue 9
Abstract
AIM: Role of Pentoxifylline is compared with placebo in the treatment of Severe Alcoholic Hepatitis. METHODS: Total 20 pts with severe alcoholic hepatitis (Maddrey DF ≥ 32) were included in the study.10 patients received pentoxifylline 400mg TDS for 4wks.And 10 patients received placebo for 4 wks. Baseline characteristics of the two groups were similar. Study was conducted for 4 wks. RESULT: Statistical Analysis was done using student’s t test. The calculated t value found to be 25.01 at 18 df which indicates the difference between Placebo and Pentoxyfylline group is highly significant (P<0.001). Higher baseline Maddrey Discriminant Function was associated with increased mortality. But Pentoxifylline lowers the Maddrey Discriminant Function thus improves survival. CONCLUSION: As compared to Placebo, Pentoxifylline reduce mortality, improved risk-benefit profile and lowers Maddrey Discriminant Function in patients with severe alcoholic hepatitis. Hence it is suggested that pentoxifylline is efficacious in treatment of severe alcoholic hepatitis
Authors and Affiliations
Rasmirekha Behera
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