Role of Platelet-rich Plasma on Nasal Mucociliary Clearance after Septoplasty - A Randomized Clinical Study
Journal Title: INTERNATIONAL JOURNAL OF SCIENTIFIC STUDY - Year 2017, Vol 5, Issue 9
Abstract
Background: Intranasal surgeries include septoplasty, endoscopic sinonasal surgeries, and endonasal dacryocystorhinostomy for different indications. During the post-operative period, the patients frequently encounter problems due to the absence of nasal mucociliary clearance (NMC) such as dryness of the nasal mucosa, crusting, bleeding from the nose, and halitosis. The present study is conducted to find the efficacy of using platelet-rich plasma (PRP) on NMC at the end of septoplasty surgery. Aim of the Study: The aim is to study the efficacy of douching the nasal cavity with PRP following septoplasty in terms of recovery of normal mucociliary function and prevention of crusting. Materials and Methods: A single-blinded, randomized, prospective study involving 74 patients divided into two groups. Group A consisted of 37 septoplasty patients in whom plasma rich with platelets was instilled in the nasal cavity and Group B 37 subjects used as control group in whom normal saline was used. Patients followed up at the 7th post-operative day and after 2 weeks. NMC was assessed pre-operatively and post-operatively. The incidence of crust formation was also observed in both the groups. Observations and Results: NMC was improved in both the groups, but there was a statistical significant early restoration of NMC in Group A. Crust formation was lower in Group A (PRP group). Conclusions: Application of PRP was an effective method of recuperating nasal mucociliary function in patients undergoing septoplasty decreasing the time taken to return to normal nasal function. PRP also reduced the incidence of crust formation.
Authors and Affiliations
Maimal Mahendra Kumar
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