Role of Porphyromonas gingivalis in rheumatoid arthritis and inflammatory spondyloarthropathies
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2014, Vol 68, Issue
Abstract
The most recent studies confirm the link between rheumatoid arthritis (RA) and periodontal disease. RA patients have higher prevalence of chronic periodontitis and periodontal disease is often more severe in these patients. Both RA and PD show similar pathophysiological mechanisms and risk factors. Autoimmunity to citrullinated peptides is the primary element in the pathogenesis of RA, not found in other diseases. Porphyromonas gingivalis, the major periodontal pathogen associated with the etiology of chronic periodontitis, is the only bacterium currently known to produce the enzyme peptidylarginine deiminase (PAD) allowing protein citrullination. This bacterium likely fulfils a significant role in the pathogenesis of RA due to its capacity for citrullination of its own protein and host peptides, which may result in a loss of immune tolerance. A few epidemiological studies also indicate the potential link between spondyloarthropathies and periodontal disease.
Authors and Affiliations
Katarzyna Białowąs, Jerzy Świerkot, Małgorzata Radwan-Oczko
Keywords
Related Articles
- EP ID EP67490
- DOI -
- Views 123
- Downloads 0
Molecular mimicry in the etiology of autoimmune diseases
There are currently more than 80 different autoimmune diseases, affecting approximately 100 million people worldwide. The etiology of most autoimmune diseases is unknown. The highest incidence of these diseases is in th...
Lymphocele – urological complication after renal transplantation
Renal transplantation is the best renal replacement treatment. It provides longer survival and a better quality of life. The outcome of renal transplantation is influenced by the occurrence of various complications, incl...
The role of intestinal microbiota in the pathophysiology of depression
Depression is a mental disorder with a high prevalence. According to World Health Organization, it is a frequent cause of disability and the leading cause of suicide, with its risk increasing with age. The disorder is co...
TGF-β1 and granulocyte elastase in the evaluation of activity of inflammatory bowel disease. A pilot study
Introduction: The aim was to assess the usefulness of TGF-β1 and elastase in the evaluation of activity of ulcerative colitis (UC) and Crohn’s disease (CD).Material and Methods: 32 patients diagnosed with UC, 31 with CD...
Oculomotor disturbances in HIV-positive individuals treated with methadone
Methadone substitution is claimed to be the most effective way of pharmacological management of human immunodeficiency virus (HIV) positive patients addicted to opioids. Possible and clinically the most relevant drug int...