Role of Pre And Postoperative Topical Cyclosporine (0.05%) on Recurrence in Recurrent And Vascularised Pterygium
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2017, Vol 16, Issue 1
Abstract
Purpose: Randomised study to evaluate the role of Cyclosporine eye drops (0.05%) pre & postoperatively on recurrence in cases of recurrent & vascularized pterygium, undergoing excision and Conjunctival Limbal Autograft with Fibrin glue. Materials and Methods: In this prospective study 100 eyes of 100 patients were taken up for study in two groups – Group A (50 eyes) and Group B (50 eyes). Only those eyes that had recurrent or vascularised pterygium were included in the study. Each case in both the groups underwent conjunctival limbal autograft with fibrin glue, after excision of pterygium. Group A received topical Cyclosporine eye drops (0.05%) pre & postoperatively 12 hourly for 04 weeks each, and in addition they also received topical steroids postoperatively for four weeks in tapering doses. Group B received standard of care treatment NSAIDs pre & postoperatively for 04 weeks each and topical steroids in tapering doses for four weeks postoperatively. Any encroachment of conjunctiva more than 1mm inside the limbus was considered as recurrence. Postoperatively patients were followed for recurrence, adverse effect and complications for 06 months in the two groups. Results: Recurrence was seen in 03(6%) of eyes in Group A and 04(8%) of eyes in Group B. Conclusion: Both pre & postoperative use of topical Cyclosporine (0.05%) can be efficacious in further reducing the chances of recurrence after pterygium surgery, although the difference observed was not statistically significant (RR-0.75, P Value-0.69).
Authors and Affiliations
Sanjay Kumar Dhar, Gaurav Kapoor, JKS Parihar
Keywords
Related Articles
- EP ID EP590950
- DOI 10.9790/0853-1601112325.
- Views 55
- Downloads 0
Malarial Perspective of the Kalita Community of Dhemaji and Dibrugarh District, Assam
Background: Malaria is one of the major public health problems in the Northeast India. Ignorance, low awareness and not prioritizing health are some of the issues in early identification and prompt treatment of diseases....
Neutrophil Extracellular Traps (NETs) “A Two way Sword” in Periodontitis
Neutrophils are the most abundant immune cells in humans and are the first line of defense against invading pathogens. They employ a wide array of anti-microbial strategies, most notably phagocytosis, Reactive Oxygen Spe...
Correlation of HbA1c with Serum Lipid Profile in Patients with Type 2 Diabetes Mellitus
Background: Diabetes mellitus is a heterogeneous group of disease, characterized by a state of chronic hyperglycemia , resulting from a diversity of etiologies, genetic and environmental factors acting jointly.Glycated h...
Role of C-Reactive Protein in Assessing Severity of Acute Pancreatitis
.
A Prospective Study of Risk Factors to Predict Conversion of Laparoscopic Cholecystectomy to Open
Background: Laparoscopic cholecystectomy (LC) is one of the most common laparoscopic procedures being performed by general surgeons all over the world. Preoperative prediction of the risk of conversion is an important as...