Role of prions in endodontics -“A Review”
Journal Title: IP Indian Journal of Conservative and Endodontics - Year 2018, Vol 3, Issue 3
Abstract
Endodontic treatment could result in cross infections from prions This could result by transmission as a result of inadequate sterilisation of the previously used endodontic instruments in an infected individual A review search was carried out online and 47 articles were found Based on the preselected inclusion and exclusion criteria 22 articles were selected The normal prion protein is found throughout the body and is noninfectious As a result of conversion in the protein structure is transformed to an infectious form The latter results in various diseases can be carried out Identification of the prion diseases can be carried out with the help of specific biomarkers found in tissue or body fluidPrion diseases cannot be cured but there progress might be slowed down The most effective form of treatment for these diseases is prevention of transmission which could be carried out by proper sterilisation and infection control These diseases run a rapid course with majority of patients dying within a year During endodontic treatment files used for biomechanical preparation are highly susceptible towards adherence of this entity owing to their unique configuration The normal sterilisation process is not adequate to eliminate the infectious form of the prions Another major source of cross infection is the air retention system in dental and suction unitPrion diseases are a group of fatal neurodegenerative disorders with no known cure Adequate precautions inspread of the infection form of prions during endodontic treatment is the most effective way of preventing these diseasesKeywords Scrapie disease CreutzfeldtJakob disease Transmissible spongiform encephalopathies Misfolded PrP
Authors and Affiliations
Anukreti Agrawal, Atul Jain, Rachana Bahuguna, Deepa Davis, Shantwana Singh
Keywords
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- EP ID EP520221
- DOI 10.18231/2456-8953.2018.0015
- Views 109
- Downloads 0
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