ROLE OF RED GRAPE EXTRACT AGAINST NICOTINE INDUCED CHANGES IN THE LUNG TISSUE OF MALE ALBINO RAT WITH REFERENCE TO AGING
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2018, Vol 5, Issue 10
Abstract
A grape (Vitis vinifera) is commercial juice product have been applied in medical research studies, showing potential benefits against the diseases. Nicotine, a major toxic component of cigarette smoking, has long been recognized to result in oxidative stress by inducing the generation of reactive oxygen species in the lung tissue. Wistar strain male albino rats were used in the present study, rats were divided into 4 groups of six in each group i) Normal Control (NC) (Control rats received 0.9% saline); ii) Nicotine treated (Nt) (at a dose of 0.6 mg/ kg body weight by subcutaneous injection for a period of 2 months); iii) Red Grape extract treated (RGEt) (red grape extract 25mg/kg body weight (after the standardization) via orogastric tube for a period of 2 months.); IV) Nicotine + Red Grape extract treatment (Nt+RGEt) as a mentioned in above Group II and Group III. The animals were sacrificed after 24 hrs after the last treatment by cervical dislocation and isolated the lung tissue. The levels of Succinate dehydrogenase (SDH), Isocitrate dehydrogenase (ICDH) and Malate dehydrogenase (MDH) were decreased in nicotine treated rats in the lung tissue and increases was observed in the combination treatment (Ni+RGEt) rats in both age groups. But at 25 mg/kg body weight were found more effective in both age groups. The Lactic dehydrogenase (LDH) activity was increased in all treated rats in the lung tissue then the control in both age groups, in nicotine treated rats in both age groups it is found more. This results stating that red grape extract treated rats are beneficial, especially for the nicotine subjects to improve the oxidative enzymes and thereby to improve the health status and life span.
Authors and Affiliations
Dr. K. Chennaiah
Keywords
Related Articles
- EP ID EP639256
- DOI -
- Views 163
- Downloads 0
PRESENCE OF SEROTONERGIC 5HT4-TYPE RECEPTORS IN BROILER’S SMALL INTESTINE
The aim of the present study was to try to determine the possible distribution of 5-HT4 receptors in small intestine of broilers (duodenum, jejunum and ileum). The disturbances of bowel function are common in broilers an...
ROLE OF RED GRAPE EXTRACT AGAINST NICOTINE INDUCED CHANGES IN THE LUNG TISSUE OF MALE ALBINO RAT WITH REFERENCE TO AGING
A grape (Vitis vinifera) is commercial juice product have been applied in medical research studies, showing potential benefits against the diseases. Nicotine, a major toxic component of cigarette smoking, has long been r...
ANTIBODY RESPONSE OF BROILER CHICKENS FED DIETS CONTAINING YEAST SINGLE CELL AS REPLACEMENT OF SOYBEAN MEAL AGAINST NEWCASTLE DISEASE
A study was conducted to evaluate the effect of replacement of soya bean meal with yeast single cell protein on broiler antibody titer against Newcastle disease virus (NDV). A total of 120 chicks out of 150 chicks were s...
CHANGES IN SERUM VASPIN AND OMENTIN AFTER SLEEVE GASTRECTOMY IN TYPE 2 DIABETIC MODEL
Background: Vaspin and Omentin showed different serum levels in diabetes and obesity. Aim: No available data demonstrating the effect of sleeve gastrectomy on Omentin and Vaspin serum levels in a model of diabetic obese...
ENHANCEMENT OF MILD HYPERTHERMIA- INDUCED APOPTOTIC CELL DEATH BY AUTOPHAGY ALTERATION IN MYELOGENOUS LEUKEMIA CELL LINE M-NFS-60
The present study investigates the effect of autophagy alteration on the cytotoxicity of mild hyperthermia (41 ºC, 1 h) toward M-NFS-60; a myelogenous leukemia cell line. Autophagy was inhibited by 5 mM NH4Cl which halts...