Role of Resolvins in Periodontal Inflammation-A Review
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 10
Abstract
The discovery of resolvins has been a major breakthrough for understanding the processes involved in resolution of inflammation. Resolvins belong to a family of novel lipid mediators that possess dual antiinflammatory and pro-resolution actions. When inflammation is initiated, goal of host response is to quickly return to homeostasis through rapid elimination of invading leucocytes. Resolution of inflammation is an active process. Cells and events are stimulated to respond, which is quite different from blocking pro-inflammatory pathways. Periodontitis is a chronic multifactorial disease. Various aspects of innate and acquired immunity play role in the pathogenesis of periodontitis. When an inflammatory event is initiated by bacteria, viruses or injury, the goal of the host response is to quickly return to homeostasis through rapid elimination of invading leukocytes.This review summarizes known signaling pathways utilized by resolvins to regulate inflammatory responses associated with the oral cavity.
Authors and Affiliations
Dr Shilpa Shetty
Keywords
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