Role of Saccharomyces boulardii in management of acute diarrhoea of children - A randomized controlled trial

Journal Title: Medpulse International Journal of Pediatrics - Year 2017, Vol 4, Issue 3


Background: Although oral rehydration solution remains the mainstay in the treatment of acute diarrhoea, this therapy does not reduce the duration of diarrhoea, prompting a growing interest in adjunctive treatments. The present study demonstrated that oral treatment with S.boulardii diminished the duration of diarrhoea from the second day after the beginning of the intervention as compared with a control group. Objective: To assess effects of Saccharomyces boulardii in acute diarrhoea. in terms of reduce duration and severity of diarrhoea. with use of Saccharomyces boulardii in dosage of 50 mg/kg/ day in two divided doses daily for five days in acute childhood diarrhoea. Material and Methods: This was a prospective randomized control trial study that was conducted in with strength of 290 cases, aged 2 months to 5 years from both sex, presenting with acute watery diarrhoea at Niramay hospital and research centre, Satara, were enrolled in the study. Informed consent was taken from the parents before enrolment. Information was collected in the form of questionnaire that included age, sex, anthropometric data and systemic details. The study population was randomly divided into 2 groups using random numbers table with 145 children in each group. Degree of dehydration of study population was assessed by who guidelines, including general condition, eagerness to drink, sunken eyes and skin turgor. Children were categorized as having mild dehydration, moderate dehydration and severe dehydration. This randomized controlled trial was conducted at Niramay hospital and research centre, Satara for 1 year duraration. Non-probability, purposive sampling was employed as sampling technique. Results: Probiotic Saccharomyces boulardii administration as add-on medication reduced the duration of illness after approximately 24 hours shows significant difference in our study favouring the use of probiotic S accharomyces in treatment group as compared to the control group. Saccharomyces boulardii shortens the duration of diarrhea, normalizes stool consistency, reduces the frequency of diarrhoea,the effect was more significant from 3rd day onwards. The appearance of the 1st semiformed stool was earlier after giving Saccharomyces boulardii. The mean number of stools per day were significantly reduced after administration of Saccharomyces boulardii. The results were obvious from 2nd day onwards. Conclusion: The use of S. boulardii along with rehydration therapy main stay of treatment in diarrheal diseases in children.So its use should be encouraged in order to reduce both mortality and morbidity in diarrhea illness.

Authors and Affiliations

Gajanan M Sirsat, D M Sankpal


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  • EP ID EP260297
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How To Cite

Gajanan M Sirsat, D M Sankpal (2017). Role of Saccharomyces boulardii in management of acute diarrhoea of children - A randomized controlled trial. Medpulse International Journal of Pediatrics, 4(3), 68-72.