Role of serotonin (5-HT)(1B) receptors in psychostimulant addiction.
Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 6
Abstract
Psychostimulant (cocaine, amphetamine and its derivatives) addiction is an important health problem with implications in social and economic life. Although mesocorticolimbic dopamine system plays a crucial role in the mechanism responsible for the rewarding effects of these drugs, recent data also show involvement of the brain serotonin (5-HT) system. In the present review we discuss the role of 5-HT(1B) receptors in the psychostimulant addiction on the base of the effects of 5-HT(1B) receptor ligands on the behavioral effects of the psychostimulants in experimental models (sensitization, intracranial self-stimulation, conditioned place preference, self-administration and extinction/reinstatement model) used to assess their addictive properties. Moreover, the effect of long-term treatment with psychostimulants on 5-HT(1B) receptors is also discussed.
Authors and Affiliations
Joanna Miszkiel, Małgorzata Filip, Edmund Przegaliński
Keywords
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