ROLE OF SERUM C-REACTIVE PROTEIN IN ANTIBIOTIC THERAPY IN NEONATAL SEPSIS
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2018, Vol 4, Issue 6
Abstract
Objective: To evaluate the adequacy of serum C-reactive protein (CRP) in diagnosing neonatal sepsis and role of CRP in determining the duration of antibiotic treatment in neonatal sepsis. Methods: In this validation study, we included 135 neonates with suspected diagnosis of sepsis within duration of nine months from September 2016 to May2017 in DHQ teaching hospital, Sargodha. Blood samples were drawn from every neonate for culture sensitivity and measurement of serum C-reactive proteins. In all suspected neonates, empirical antibiotics e.g. Gentamycin or Ampicillin were started after taking blood samples. Serum CRP levels >5 mg/dl were marked as positive results. 2nd blood samples for measurement of serum CRP were taken after 72 hours of the first sample. There were two primary endpoints; one to determine the sensitivity and specificity of CRP against blood culture and second was to determine the negative predictive value of CRP in determining the duration of anti-biotic in neonates presenting with sepsis. Results: Out of these 135 babies, 102 (75.5%) were confirmed to have sepsis using blood culture reports. CRP results were Positive in 85 (62.9%) neonates on first baseline measurement and were positive in 103(76.29%) neonates after 72 hours of admission. The sensitivity of CRP in diagnosing sepsis was 98.03%, specificity was 91.0%, positive predictive value (PPV) was 97% and negative predictive value (NPV) was 93.7%. The mean duration of antibiotic treatment in CRP guided group was 5.03 days versus 7.02 days in standard treatment duration group (p-value <0.001). The NPV of CRP in determining the duration of antibiotics was 100.0%. Conclusion: Serum CRP level is a reliable test in establishing the diagnosis of neonatal sepsis. It accurately monitors the duration of antibiotic therapy and results in significant reduction in the treatment duration of neonatal sepsis.
Authors and Affiliations
Dr. Muhammad Umer Iqbal Butt
Keywords
Related Articles
- EP ID EP664720
- DOI -
- Views 174
- Downloads 0
SOFOSBUVIR, THE NUCLEOTIDE ANALOGUE AGAINST HEPATITIS C VIRUS – A REVIEW
Infectious liver disease caused by the hepatitis C virus. There is no vaccine and it commonly becomes chronic. Traditional treatment is limited by frequent adverse effects and low efficacy. The current therapy for HCV in...
ROLE OF FOXO PROTEIN IN OSTEOARTHRITIS AND ITS TREATMENT: GAME CHANGER IN THE FIELD OF RHEMATOLOGY
Osteoarthritis is the most common age related disease affecting older individual. Most commonly it involves weight bearing joints in human. Reduced expression of FOXO proteins has been found to be associated with develop...
TRI-MARMA THE CLINICAL AND SURGICAL PERSPECTIVE
Marma is one of the special aspects deeply elaborated by Ayurveda. Marma are several vital points on the body having importance regarding traumatic effect. These points when exposed to trauma generate the symptoms from p...
AN OVERVIEW OF FACTORS INFLUENCING THE OCCURRENCE OF POST-OPERATIVE WOUND INFECTION
Microbial infections and sepsis are observed as the significant problem in modern surgery. Various factors that are influencing surgical site and other wound infections are studied. The association of surgical procedures...
DEMOGRAPHIC CHARACTERISTICS OF HOSPITALIZED CHILDREN WITH FAVISM IN AL-FALLUJAH CITY: A CASE SERIES
Background: Glucose-6-phosphatase dehydrogenase (G6PD) deficiency is one of the most common X-linked inherited pediatric disorder. Acute hemolytic anemia can be developed in children with G6PD deficiency after ingestion...