ROLE OF SODIUM AND POTASSIUM AS A PROGNOSTIC BIOMARKER OF SICKLE CELL DISEASE
Journal Title: INTERNATIONAL JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH - Year 2015, Vol 3, Issue 1
Abstract
Sickle cell disease (SCD) affects millions of people worldwide. It is the second most common haemoglobinopathies next to thalassaemia in India. In Maharashtra the prevalence of disease ranges from 1.9% to 33.5% . We are residing in an endemic zone and the prevalence of sickle cell anemia here in Vidarbha region of Maharashtra is from 9.4% to 22.2%. In addition to the abnormality in hemoglobin, SS erythrocytes exhibit changes in membrane permeability, possibly owing to alterations in the membrane cytoskeleton. It has been well documented that deoxygenated sickle erythrocytes exhibit increased Na and K fluxes, with net cellular Na+ gain and K+ loss Sodium (Na+) regulates the amount of total body water and plays a critical role in electrical communication especially in the brain, nervous systems and muscles.
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