ROLE OF SODIUM AND POTASSIUM AS A PROGNOSTIC BIOMARKER OF SICKLE CELL DISEASE
Journal Title: INTERNATIONAL JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH - Year 2015, Vol 3, Issue 1
Abstract
Sickle cell disease (SCD) affects millions of people worldwide. It is the second most common haemoglobinopathies next to thalassaemia in India. In Maharashtra the prevalence of disease ranges from 1.9% to 33.5% . We are residing in an endemic zone and the prevalence of sickle cell anemia here in Vidarbha region of Maharashtra is from 9.4% to 22.2%. In addition to the abnormality in hemoglobin, SS erythrocytes exhibit changes in membrane permeability, possibly owing to alterations in the membrane cytoskeleton. It has been well documented that deoxygenated sickle erythrocytes exhibit increased Na and K fluxes, with net cellular Na+ gain and K+ loss Sodium (Na+) regulates the amount of total body water and plays a critical role in electrical communication especially in the brain, nervous systems and muscles.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP490121
- DOI -
- Views 98
- Downloads 0
ROLE OF CALPONIN IN PLATELET FUNCTION AND CARDIOVASCULAR DISEASE
Calponin is an actin binding protein known to convert external mechanical signals into intracellular chemical signals in different types of cells. Calponin especially Calponin2 is found in platelets and macrophages. Macr...
FABRICATION OF FLANGELESS COMPLETE DENTURE TO IMPROVE ESTHETICS: A CASE REPORT
Face is the most important part which determines one’s social acceptance. Loss of teeth affects the facial appearance and also may create psychological trauma in a patient. Prosthesis may affect the appearance of a perso...
NON-UNION OF PROXIMAL POLE SCAPHOID FRACTURE TREATED WITH RETROGRADE HERBERT SCREW FIXATION TECHNIQUE
Treatment of proximal pole Scaphoid fractures warrants urgent attention as they are prone to osteonecrosis and non-union with an incidence of 53%-92%. We report a case of proximal pole scaphoid fracture which was initial...
“CLINICAL RELEVANCE OF CYTOKINES GENE POLYMORPHISM (CGP) IN RECOVERY OF HEMORRHAGIC SHOCK PATIENTS”
Severe trauma complicated with multiple organ dysfunction syndromes (MODS) are among the leading causes of deaths in intensive care units. Alarmingly, the mortality rate primarily due to multiple organ dysfunctions (MOD)...
“ROLE OF EARLY SECOND TRIMESTER HIGH SENSITIVITY C – REACTIVE PROTEIN FOR PREDICTION OF ADVERSE PREGNANCY OUTCOME”
A prospective cohort study was carried out to evaluate the role of early second trimester high sensitivity C - reactive protein for prediction of adverse pregnancy outcomes. Total 150 early second trimester primigravidae...