Role of Soluble Heat Shock Proteins 70 in Severity of Dengue Infection.
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2017, Vol 2, Issue 6
Abstract
Objective: to prove the role of soluble HSP 70 in the severity of dengue infection by comparing the level of soluble HSP 70 in patients who diagnosed as dengue fever (DF), dengue hemorrhagic fever (DHF) and in healthy people. Methods: This was a prospective and longitudinal study, samples were taken by using consecutive sampling with a sample size were 22 DF patients, 20 DHF patients and 20 healthy people as a control group. Soluble HSP 70 in serum was measured by an enzyme-linked immunosorbent assay (ELISA). Results: The soluble HSP 70 was significantly increased (p=0.003) in DHF patients (0.33 ± 0.17 ng/ml) compared to in DF patients (0.149 ± 0.19 ng/ml) and control group (0.147 ± 0.37 ng/ml), but there was not significantly increased (p=0.241) in DF patients compare within control group. Conclusion: This result suggesting that soluble HSP 70 may play important roles in the severity of dengue infection.
Authors and Affiliations
Dr. Nurfadly Zain
Keywords
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