Role of the spleen in patients with liver cancer and cirrhosis
Journal Title: Journal of Surgery : Concepts & Practice - Year 2023, Vol 28, Issue 4
Abstract
The spleen is the largest lymphoid organ that can affect the immunological microenvironment in the liver via the portal system. Patients with liver cancer, often develop hypersplenism and splenomegaly from underlying cirrhosis and portal hypertension. The malfunction of the spleen not only induces hepatic fibrogenesis, but also changes the immune responses in the liver, so that liver cirrhosis accelerates while liver regeneration subdues. As a result, the hepatic microenvironment and the rest of the immune system reach a “tumor progressing” or “tumor tolerant” state. Splenectomy has been shown to improve immune responses, liver function and general condition in patients with liver cancer. Hence, splenectomy may possibly improve the tolerance in live cancer patients for other anticancer treatments. However, the long-term benefits and effects on the overall survival of concomitant hepatectomy and splenectomy for liver cancer patients with portal hypertension and hypersplenism still remain controversial.
Authors and Affiliations
Jessica CHANG, Xuxiao CHEN, Yongjun CHEN
Keywords
Related Articles
- EP ID EP750902
- DOI 10.16139/j.1007-9610.2023.04.018
- Views 4
- Downloads 0
Current status of high-positioned digestive tract reconstruction after laparoscopic proximal stomach and lower esophagus resection through the abdominal-left diaphragmatic approach for adenocarcinoma of esophagogastric junction
In recent years, the rising incidence of adenocarcinoma of esophagogastric junction (AEG) and the subsequent surge in early detections have transformed the surgical treatment of AEG into a topic of substantial interest....
Review and prospect of neoadjuvant chemoradiotherapy combined with immunotherapy in locally advanced rectal cancer
For locally advanced rectal cancer (LARC), the standard treatment of neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision (TME) leaded to limited tumor regression grade and organ preservation rate,...
Research on standardized treatment of spontaneous rupture of hepatocellular carcinoma
Occurrence and treatment of hypertension associated with targeted therapy in hepatocellular carcinoma
Current status of minimally invasive surgery of gastroesophageal reflux disease
Gastroesophageal reflux disease (GERD) is one of the common gastrointestinal diseases. The treatment options for GERD includes lifestyle changes, medication, and surgery. With the development of surgical technology, mini...