Role of Thrombopoietin in the Diagnosis of Ovarian Cancer: A Brief Review
Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 4
Abstract
ABSTRACT Ovarian Cancer (OC) is the most fatal condition among all gynaecologic malignancies. The survival rate of early and advance stage of OC is 80-90% and 15-20% respectively. This data constitutes the need of a novel biomarker for early diagnosis, which may distinguish malignant tumours from benign ovarian cysts. Presently in practice there are three screening techniques: bimanual pelvic examination, serum Cancer Antigen (CA) 125 and transvaginal ultrasound. Bimanual pelvic examination can detect only 1 in 10,000 ovarian cancers in women presenting to the clinic. CA 125 is raised in 80% of cases of ovarian carcinoma; however, if the carcinoma is limited to ovary, the raised value is seen only in 50% of women. It is mainly useful in postmenopausal women. Ultrasonography also lacks specificity and sensitivity, apart from being costly as a screening test. Studies are going on for search of a biomarker, which may complement CA 125. Most common among these are Human Epididymis Protein 4 (HE4), Thrombopoietin (TPO), CA19-9, human kallikrein 10, human kallikrein 6, osteopontin, claudin 3, DF3 (murine monoclonal antibody), vascular endothelial growth factor, MUC1, mesothelin etc. In 2008, FDA approved the use of HE4 assay for monitoring of progressive disease in patients with epithelial ovarian cancer. Similarly TPO also holds the promise of being a biomarker to complement CA125 and many studies are indeed available to support the association of TPO and OC. In this review article we have summarised and analysed such studies.
Authors and Affiliations
Amar Ranjan, Rajani Anand, Iffat Jamal, Amrendra Kumar, Ritesh Kumar
Keywords
Related Articles
- EP ID EP524024
- DOI 10.7860/JCDR/2018/30902.11350
- Views 49
- Downloads 0
Mental Health and Old Age: A Qualitative Study in Iranian Population
Introduction: Health, which usually declines with age, is one of the determinants of quality of life. Mental health disorder is one of the most common health-threatening problems of older age. Aim: The present qualitativ...
New Vision for Improving the Oral Health Education of Visually Impaired Children- A Non Randomized Control Trial
Introduction: Visually impaired people have poorer oral hygiene when compared to others. Therefore, there is a necessity for individual training by making awareness in oral care and plaque control so as to improve their...
Facial Nerve Paralysis Due to Aviation Barotrauma in a Child: A Case Report
ABSTRACT Facial nerve paralysis due to aviation barotrauma is a rare occurrence that has previously only been seen in adults. This case report describes the presentation of baroparesis in a female child, which posed uniq...
Double Barrel Oesophagus- A Case Report
ABSTRACT Double barrel Oesophagus is a rare entity that involves a mucosal injury, thereby creating of a true and false lumen within the oesophagus. Diagnostically it is important to differentiate complete and partial di...
Unilateral Paravertebral Block: An Alternative to Conventional Spinal Anaesthesia for Unilateral Uncomplicated Inguinal Hernia Repair
ABSTRACT Introduction: Inguinal hernia repair can be performed under general anaesthesia or various regional anaesthesia techniques like spinal, epidural or nerve blocks like hernia block or Paravertebral Block (PVB). Th...