Role of TRPV1/TRPA1 in hyperalgesia after ophthalmology
Journal Title: Eye Science (Yanke Xuebao) - Year 2022, Vol 37, Issue 9
Abstract
The postoperative pain of ophthalmic surgery has been widely concerned in recent years. Some patients show enlarged painful areas and neurophotophobia postoperatively. This abnormal increase in noxious irritant signals after surgery is called hyperalgesia. The development of hyperalgesia can result in delayed postoperative recovery for patients. In addition, hyperalgesia can also cause discomfort for patients, and induce patients to use more analgesics, which can have related side effects. TRPV1/TRPA1 is a nociceptor, which can be specifically activated by nociceptive stimuli to induce hyperalgesia. Nevertheless, the pathogenesis of hyperalgesia after ophthalmology surgery has not been fully elucidated, and the molecular signal pathway of how TRPV1 sensitizes and causes hyperalgesia is not yet clear.
Authors and Affiliations
Zexi YE, Xiaoliang GAN
Keywords
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- EP ID EP763744
- DOI 10.3978/j.issn.1000-4432.2022.07.03
- Views 17
- Downloads 0
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