Role of Various Immune Cells in the Tumor Microenvironment
Journal Title: Diseases & Research - Year 2023, Vol 3, Issue 1
Abstract
The tumor microenvironment (TME) has numerous promotive and suppressive effects on tumor growth. The TME harbors adaptive and innate immune cells such as T cells, B cells, natural killer (NK) cells, macrophages, neutrophils, and dendritic cells. The development, survival, and invasion of tumor cells at the tumor site are accompanied by various interactions with several biomolecules and cells. Identification of cells and molecules, differences between their roles in classical immune system and those that operate in the TME enhances the understanding of biological principles governing cancer cell mobility and plasticity to survive in adverse conditions against various defensive immune cells. Understanding the role of cellular and non-cellular components of TME in tumor growth and metastasis (pro and anti-tumor) is essential in designing appropriate molecular targeted therapies. Possibly, the accumulated knowledge would allow us to develop strategies to overcome major therapeutic barriers that operate in the TME such as cancer immune escape, stromal challenges, antigen escape, and invasion regulated by genetic and epigenetic modifications in the tumor cells and immunosuppressive TME. There are still many unknowns about the diversity, plasticity, modulators of adaptive and innate immune cells, and the mechanisms of cancer escape from immune cell surveillance. This review accounts for current understanding of immune cells’ function and their cross interaction in the TME.
Authors and Affiliations
Anjali Bhargav, Nishka Bhalla, Sneha Manoharan, Gurbind Singh, Sandeep Kumar Yadav, Aloukick Kumar Singh
Keywords
Related Articles
- EP ID EP740143
- DOI 10.54457/DR.202301006
- Views 33
- Downloads 0
A Commentary on the Natural Disease Progression Sequence of Chronic Hepatitis B
Hepatitis B virus (HBV), an ancient family of hepatotropic DNA viruses with origins dating back millions of years, remains a major burden to human health today, although hepatitis B vaccines have dramatically reduced the...
Clinical Progress of Adjuvant Chemotherapy in Locoregionally Advanced Nasopharyngeal Carcinoma
Concurrent chemoradiotherapy (CCRT) is the foundational standard-of-care for patients with locoregionally advanced nasopharyngeal carcinoma (LANPC). Adding adjuvant chemotherapy (AC) or induction chemotherapy (IC) to CCR...
Role of Various Immune Cells in the Tumor Microenvironment
The tumor microenvironment (TME) has numerous promotive and suppressive effects on tumor growth. The TME harbors adaptive and innate immune cells such as T cells, B cells, natural killer (NK) cells, macrophages, neutroph...
ransient Hypopituitarism in a Patient Developing Diabetic Ketoacidosis after COVID-19: Case Report
Since the beginning of the novel coronavirus disease (COVID-19) pandemic, many papers have been published about the association between COVID-19 and various endocrine abnormalities. Accumulated data so far reveal that hy...
Bioinformatics Analysis to Screen the Key Genes and Pathways in the Formation of Early T-cell Precursor Acute Lymphoblastic Leukemia
Purpose Early T-cell precursor acute lymphoblastic leukemia (EPT-ALL) is a rare type of ALL that shows genetic characteristics of both ALL and acute myeloid leukemia (AML) but has a poorer prognosis and a higher recurren...