ROLE OF VITAMIN D AS AN ANTI-PROLIFERATIVE COMPOUND ON PROSTATE CANCER
Journal Title: Acta Facultatis Medicae Naissensis - Year 2013, Vol 30, Issue 0
Abstract
The reason of prostate cancer is the mutation in the prostate cell. The present study was aimed at determining the effects of different concentrations of vitamin D on the anti-proliferative action of 24,25(OH)2D3 applied on LNCaP (cell line of human prostate cancer) cells. It was evident from the results that vitamin D having concentrations of 10-9nM showed the best anti-proliferative action on prostate cancer cells (LNCaP cells) compared to other concentrations used. Most of the receptors were expressed at 10-9nM resulting clear band in agarose gel image. Results also revealed that both nVDR and AR receptors (androgen receptors) were expressed well when treated with 10-9nM and 10-10nM concentrations of 24,25(OH)2D3. These findings confirm the potential use of vitamin D as an anti-proliferative compound against prostate cancer cells.
Authors and Affiliations
Ahmad Humayan Kabir, Ferdhos Khan, Mamunur Rashid Sarkar
Keywords
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- EP ID EP121057
- DOI 10.2478/afmnai-2013-0003
- Views 125
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