Role of Vitamin E and Vitamin A in Oral Mucositis Induced by Cancer Chemo/ Radiotherapy- A Meta-analysis
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 5
Abstract
Introduction: Oral mucositis is known to hamper the quality of life in patients treated for oral cancer. Many pharmacological agents have been tried and tested in its management, especially vitamin supplements including A, E and their combinations. Aim: A Meta-analysis was carried out to evaluate the efficacy of vitamins individually used for prevention or treatment of oral mucositis separately for chemotherapy, concurrent chemo radiotherapy, radiotherapy and Haematopoietic Stem Cell Transplantation (HSCT) individuals. Materials and Methods: The literature study was done using PUBMED, MEDLINE, EBSCO, GOOGLE SCHOLAR and COCHRANE data bases with keywords vitamin A, vitamin E, vitamin B, vitamin C, Oral mucositis, Chemotherapy, Radiotherapy, Concurrent chemo radiotherapy and Haematopoietic stem cell transplantation individually, from the year 1980 to 2016. Only randomized controlled trials were included. The data was extracted, tabulated and was subjected to statistical analysis with CI of 95%. Results: Among 201 subjects the analysis clearly demonstrated a male predominance to females in studies where male to female ratio was given. Out of 8 studies, 2 were studies in children and remaining 6 studies concentrated on adult population. WHO and NCI-CTC criteria were followed except for one study which used customised assessment. A meta-analysis was performed regarding usage of topical medication of Vitamin E group in all three cancer treatment modalities, which showed significant reduction in oral mucositis (p < 0.001). There was reduced oral mucositis in a small group of patients with Vitamin A when compared to controls. No information on the agent used for chemotherapy, the dose of radiotherapy and the type of tumours in 4 studies. Conclusion: Topical Vitamin E had performed better on oral mucositis than Vitamin E systemic administration. Though the efficacy of topical treatment with Vitamin A showed reduction in oral mucositis, it was evaluated in a very small sample which cannot be attributed to a larger sitting.
Authors and Affiliations
NALLAN CSK CHAITANYA, Arvind MUTHUKRISHNAN, Dara Balaji Gandhi Babu, Chinta Sanjeeva Kumari, Madishetty Adi Lakshmi, Gayathri palat, Khwaja Shoeb Alam
Keywords
Related Articles
- EP ID EP347251
- DOI 10.7860/JCDR/2017/26845.9905
- Views 88
- Downloads 0
A Cutaneous Ciliated Cyst Mımicking a Pilonidal Cyst
ABSTRACT Cutaneous Ciliated Cyst (CCC) is a benign tumor encountered especially in the upper extremities and the perineal area in young women after puberty. CCC is located in the subcutaneous tissue in deep dermis, and...
Morphological and Morphometric Study of Coronary Sinus in North Indian Population
Introduction: Coronary sinus (CS) is the largest vein draining the blood from heart. It is a muscular tube of about 2 cm to 3 cm length and 1 cm in caliber. It has become a clinically important structure through its role...
To Evaluate and Compare Periodontal Disease and Smoking as a Parallel Risk Factor for Systemic Health by Gauging the Serum C-Reactive Protein Levels
Introduction: Physiologic and metabolic changes that occur immediately after a damage or disease are known as Acute Phase Reaction (APR). Acute Phase Proteins (APP) are blood proteins secreted by hepatocytes during APR C...
Effects of Tamoxifen-Loaded Solid Lipid Nanoparticles on Kidney and Liver of Female Ovariectomized Rats
Introduction: Tamoxifen (TMX) has harmful dose-dependent long-term side effects such as liquid retention in postmenopausal breast cancer patients. Although, encapsulation of low-dose TMX in colloidal delivery systems hav...
Safety Attitudes among Doctors and Nurses in an Emergency Department of an Australian Hospital
ABSTRACT Introduction: Safety attitudes have been investigated in a number of countries across different hospital departments, however there are few studies including Emergency Departments. Aim: To investigate doctors’ a...