Roles of autophagy and p62 /SQSTM1 in hepatic ischemia-reperfusion
Journal Title: Biomedical Transformation - Year 2021, Vol 2, Issue 1
Abstract
Autophagy is a lysosomal dependent degradation system, and p62 itself is an important protein carrier to facilitate the removal of damaged proteins by proteasomes and autophagosomes. p62 plays an important role in selective autophagy such as mitochondrial autophagy. p62 binds to Keap1 and clears Keap1 through autophagy, leading to increased levels of free Nrf2. Nrf2 can promote the expression of p62, glutathione (GSH) and thioredoxin (TXN). Therefore, autophagy, p62 and Nrf2 are closely related and mutually regulated. However, in the process of hepatic ischemia-reperfusion injury, these molecules in hepatocytes may participate in the process of cell death, and the specific mechanism still needs to be further studied.
Authors and Affiliations
Zhang Haiming, Zhu Zhijun
Keywords
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- EP ID EP767197
- DOI 10.12287/j.issn.2096-8965.20210110
- Views 10
- Downloads 0
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