Rosuvastatin is Superior Compared to Simvastatin and Atorvastatin to Induce Endothelial Progenitor Cells Migration
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 5
Abstract
ABSTRACT Introduction: Statins have shown to improve Endothelial Progenitor Cells (EPCs) function, however no comparison has been done between various statins effectivity to induce EPCs migration. Aim: This study compared simvastatin, atorvastatin and rosuvastatin treatment on impaired EPCs from Coronary Artery Disease (CAD) patients. Materials and Methods: EPCs were isolated, cultivated and divided into untreated group (control), simvastatin (dose 0.1, 0.25, 0.5 mM), atorvastatin (0.1, 0.25, 0.5 mM), rosuvastatin (0.1, 0.25, 0.5 mM). EPCs migration was evaluated with boyden chamber assay. ANOVA, pearson correlation and linear regression test were done using SPSS 25.0. Results: This research showed that simvastatin, atorvastatin, and rosuvastatin increased EPCs migration in dose dependent manner (p<0.05). Regression test showed that simvastatin treatment was responsible for 92.9% of EPCs migration, while atorvastatin was 75.5% and rosuvastatin was 65.6%. Rosuvastatin treatment dose 0.5 mM have the highest EPCs migration effect (195,750.00±5,809.48) compared to simvastatin (123,750.00±9,367.50, p≤0.001) and atorvastatin (156,375.00±12,392.03, p≤0.001) at the same dose. Conclusion: Rosuvastatin treatment has higher EPCs migration effect compared to simvastatin and atorvastatin. This suggests that rosuvastatin might be preferable to improve EPCs migration in CAD patients.
Authors and Affiliations
Yudi Her Oktaviono, Makhyan Jibril Al Farabi, Feranti Meuthia, Tyagita Verdena Rani Savitri, Djoko Soemantri
Keywords
Related Articles
- EP ID EP584193
- DOI 10.7860/JCDR/2019/41485.12841
- Views 119
- Downloads 0
Myoclonic Seizures and Lactic Acidemia in a Term Newborn Born with No History of Asphyxia
ABSTRACT We here report an unusual case of a term neonate who presented with myoclonic seizures and lactic acidemia at 30 hours of life, who was later on diagnosed as a case of pyridoxine dependant epilepsy. Pyridoxine...
Evaluation of the Nature of Thyroid Nodules by Duplex Ultrasound and Assessment of the Diagnostic Accuracy of TIRADS Classification
Introduction: Ultrasound (US) is the primary modality used to assess the thyroid glands. However, the terminology used by the radiologist is not easy for clinicians to understand. Thyroid Imaging Reporting and Data Syste...
Ciprofloxacin Induced StevensJohnson Syndrome
Images in Medicine
Thoracoscopic Diaphragmatic Plication for Eventration in Pregnant Woman: A Case Report
Diaphragmatic eventration is an uncommon malady, underdiagnosed and often treated only in emergent situations. Eventration of the diaphragm is best treated by plication of diaphragm with or without meshplasty. Various st...
Analysis of Risk Factors and Outcome of Renal Failure in Benign Prostatic Hyperplasia
ABSTRACT Introduction: Benign Prostatic Hyperplasia (BPH) is one of the most common diseases of aging men, affecting 50% by 60 years of age and increasing to 90% by ninth decade of life. A small percentage of men with ob...