Rosuvastatin is Superior Compared to Simvastatin and Atorvastatin to Induce Endothelial Progenitor Cells Migration
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 5
Abstract
ABSTRACT Introduction: Statins have shown to improve Endothelial Progenitor Cells (EPCs) function, however no comparison has been done between various statins effectivity to induce EPCs migration. Aim: This study compared simvastatin, atorvastatin and rosuvastatin treatment on impaired EPCs from Coronary Artery Disease (CAD) patients. Materials and Methods: EPCs were isolated, cultivated and divided into untreated group (control), simvastatin (dose 0.1, 0.25, 0.5 mM), atorvastatin (0.1, 0.25, 0.5 mM), rosuvastatin (0.1, 0.25, 0.5 mM). EPCs migration was evaluated with boyden chamber assay. ANOVA, pearson correlation and linear regression test were done using SPSS 25.0. Results: This research showed that simvastatin, atorvastatin, and rosuvastatin increased EPCs migration in dose dependent manner (p<0.05). Regression test showed that simvastatin treatment was responsible for 92.9% of EPCs migration, while atorvastatin was 75.5% and rosuvastatin was 65.6%. Rosuvastatin treatment dose 0.5 mM have the highest EPCs migration effect (195,750.00±5,809.48) compared to simvastatin (123,750.00±9,367.50, p≤0.001) and atorvastatin (156,375.00±12,392.03, p≤0.001) at the same dose. Conclusion: Rosuvastatin treatment has higher EPCs migration effect compared to simvastatin and atorvastatin. This suggests that rosuvastatin might be preferable to improve EPCs migration in CAD patients.
Authors and Affiliations
Yudi Her Oktaviono, Makhyan Jibril Al Farabi, Feranti Meuthia, Tyagita Verdena Rani Savitri, Djoko Soemantri
Keywords
Related Articles
- EP ID EP584193
- DOI 10.7860/JCDR/2019/41485.12841
- Views 104
- Downloads 0
Sclerosing Extramedullary Haematopoietic Tumour Presenting as Bilateral Gluteal Abscess in a Patient with Chronic Myelogenous Leukaemia
ABSTRACT Sclerosing Extramedullary Haematopoietic Tumours (SEMHT) are found to be associated with Chronic Myeloproliferative Neoplasms most commonly reported in the skin, lacrimal system, orbit, omentum and liver. A 26-y...
Efficacy of Yoga as an Add-on to Physiotherapy in the Management of Patients with Paraplegia: Randomised Controlled Trial
ABSTRACT Introduction: Traumatic Spinal Cord Injury (SCI) is a leading cause of disability. Varying injury level and severity generate a spectrum of neurological dysfunction and a reduction in long-term Quality of Life (...
Spectrum of Haemoglobinopathies: A Hospital Based Study in Uttarakhand
Introduction: Haemoglobinopathy is a worldwide inherited problem as recognized by WHO and care of affected patients incurs heavy expense on the limited resources of developing countries. There is a need for prevention of...
Comparative Evaluation of Colour Stability and Surface Hardness of Methacrylate Based Flowable and Packable Composite -In vitro Study
Introduction: With the advent of new technology in material sciences in recent years, the quality of composite resin restorations has improved; however, discolouration and wear of composite resin materials remains to be...
Morphometric Analysis of Odontometric Parameters for Gender Determination
Introduction: In contemporary human population, males exhibit larger size of dentition as compared to females. Additionally, these odontometric parameters show variation in members of same species and also show regional...