Routine Cytogenetic Analysis of Chromosome Abnormalities in Acute Lymphoblastic Leukemia
Journal Title: International Journal of Biomedical Research - Year 2015, Vol 6, Issue 9
Abstract
Acute lymphoblastic leukemia (ALL) is the most common cancer in children. Acquired chromosomal and genetic abnormalities have been used to define distinct biological and clinical subtypes of ALL. These aberrations have been shown to be associated with patient outcome and are used to direct therapy. Conventional cytogenetics analysis (CCA) is currently the gold standard to detect chromosome abnormalities in hematological malignancies. In this review we briefly describe the CCA methodology, advantages and limitations of CCA, the main chromosomal abnormalities and their prognostic significance in ALL.
Authors and Affiliations
Chin Yuet Meng
Keywords
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- EP ID EP391839
- DOI 10.7439/ijbr.v6i9.2456
- Views 191
- Downloads 0
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