Rozdzielenie mieszanin racemicznych za pomocą krystalizacji. Część 2, Rozdzielenie racematów z utworzeniem diastereoizomerycznych soli
Journal Title: Wiadomości Chemiczne - Year 2015, Vol 69, Issue 1
Abstract
The enantioseparation of a racemate through diastereomeric salt formation with a resolving agent is one of the most attractive methods for obtaining an enantiopure compound, with advantages such as its simplicity in operation, recyclability of the chiral source, and applicability on an industrial scale. In this method the enantiomers are converted into a diastereomeric salt pair by reaction with a single enantiomer of resolving agent. The diastereomers are then separated by crystallization taking advantage of the different solubility of the two compounds [1–3]. The formation of diastereomers, to be separated afterward, usually consists of salt formation with a resolving agent of opposite acide-base character (Scheme 1, 9). In this process, the molecules of opposite character (amine and acid) recognize each other by various interactions on the basis of their molecular structures and functional groups [3]. Using this method can be obtained a series of enantiomerically pure amines (Scheme 2–8) [4–26] and acids (Scheme 10–17) [27–41] which may be valuable substrates for asymmetric synthesis. The conditions for enantioseparation play an important role. On the efficiency of the enantioseparation has an effect the resolving agent, nature of the solvent or just its dielectric constant and the character and amount of some supplementary additives.
Authors and Affiliations
Renata Kołodziejska, Ewa Kopkowska, Aleksandra Karczmarska-Wódzka, Beata Augustyńska
Keywords
Related Articles
- EP ID EP585074
- DOI -
- Views 158
- Downloads 0
Struktura a patogeneza chorób związanych z ekspansją powtórzeń CNG
CNG repeats (N stands for one of the four natural nucleotides) are a special class of microsatellite sequences of the human genome. They are most often found in exons, in their coding parts as well as in the 5’ or 3’ unt...
Ciecze jonowe oraz potencjalne obszary ich zastosowań w przemyśle chemicznym
Ionic liquids (ILs) compose a group of chemical compounds of ionic nature consisting of organic cation and inorganic or organic anion, whose melting point does not exceed 100°C (373,15 K). These compounds play a very imp...
Fotoreaktwne poliakrylanowe kleje samoprzylepne
Pressure-sensitive adhesives (PSAs) are non-metallic materials used to bond other materials, mainly on their surfaces through adhesion and cohesion. Adhesion and cohesion are phenomena, which may be described thermodynam...
Zygmunt Krasiński wobec odkryć przyrodniczych
Brak
Biologiczne zastosowania nanoluminoforów domieszkowanych lantanowcami
Fluorescence is one of the most commonly used methods of biodetection, mainly due to the high sensitivity, non-invasiveness, simplicity, and also due to the availability of the whole range of powerful light sources, a wi...