RP-HPLC PDA METHOD FOR ESTIMATION OF ZANAMIVIR IN API AND PHARMACEUTICAL FORMULATION
Journal Title: Indo American Journal of Pharmaceutical Sciences - Year 2018, Vol 5, Issue 4
Abstract
A rapid and precise Reverse Phase High Performance Liquid Chromatographic method has been developed for the validated of Zanamivir in its pure form as well as in tablet dosage form. Chromatography was carried out on Sunfire C18 (4.6×150mm, 5µ) column using a mixture of Methanol and water (95:5 v/v) as the mobile phase at a flow rate of 1.0ml/min, the detection was carried out at 285nm. The retention time of the Zanamivir was 2.6 ±0.02min. The method produce linear responses in the concentration range of 40-200µg/ml of Zanamivir. The method precision for the determination of assay was below 2.0%RSD. The method is useful in the quality control of bulk and pharmaceutical formulations. Keywords: Zanamivir, RP-HPLC, validation.
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