Ruxolitinib-associated tuberculosis – A rare complication of a novel drug!
Journal Title: International Journal of Medical Science and Public Health - Year 2017, Vol 6, Issue 3
Abstract
Primary myelofibrosis (PMF) is a myeloproliferative disorder characterized by bone marrow fibrosis, abnormal cytokine expression, abnormal proliferation of megakaryocytes, and splenomegaly. Ruxolitinib (INCB018424) is a novel nonspecific Janus-like kinase inhibitor available for the management of PMF as it reduces spleen size and gives significant symptomatic relief. Very few case reports are available depicting opportunistic infections associated with this drug. We present a case of 35-year-old female - A known case of PMF on follow-up since 7 years. She was started on ruxolitinib in view of symptomatic progressive splenomegaly and weight loss. She was asymptomatic till 4th month of starting drug when she developed fever, body ache, and right axillary swelling. The right axillary lymph node biopsy revealed necrotizing granulomatous lymphadenopathy of tuberculous etiology (acid-fast bacilli [AFB] positive). X-ray of the chest was normal. She was started on antituberculosis (TB) treatment, and ruxolitinib was also continued. Patient is currently asymptomatic and has gained weight. She is on continuation phase of anti-TB treatment.
Authors and Affiliations
Vinod R Patil, Chandrakala S, Nilesh P Wasekar, Farah Jijina, Aniket B Mohite
Keywords
Related Articles
- EP ID EP310700
- DOI 10.5455/ijmsph.2017.0846912092016
- Views 66
- Downloads 0
Pattern of rheumatic heart disease in Bareilly
Background: Valvular heart disease is a leading cause of morbidity and mortality in India. Echocardiography (ECHO) remains the gold standard for diagnosis and periodic assessment of patients with valvular heart disease....
A questionnaire-based cross-sectional study on self-medication practices among undergraduate medical students of GMERS Medical College, Valsad, Gujarat
Background: Self-medication is widely practiced worldwide, especially developing country as many drugs are dispensed over the counter without prescription and may lead to irrational usage of drugs. Self-medication common...
Impact of drug-related problems and clinical pharmacist interventions on therapeutic outcomes of the patients admitted to a tertiary care hospital
Background: A drug-related problems (DRPs) are defined as an event or circumstance involving drug therapy that actually or potentially interferes with desired health outcomes. The DRPs can occur at any level of its usage...
Opportunistic screening for diabetes mellitus among adults attending a primary health center in Puducherry
Background: More than half of cases with diabetes mellitus in India remain undiagnosed. Considering factors on yield and availability of resources, population-based screening is not recommended in low- and middle-...
Pattern of peripheral arterial disease and serum lipid profile in patients with diabetes mellitus
Background: Diabetes mellitus is rapidly rising. Majority of patients with diabetes mellitus also have dyslipidemia [diabetic dyslipidemia (DD)]. DD has been found to be associated with increased risk of peripheral a...