SAFETY AND EFFICACY OF COMBINATION OF MONTELUKAST AND LEVOCETRIZINE IN THE SYMPTOMATIC TREATMENT OF ALLERGIC RHINITIS AND ASTHMA: PHASE IV CLINICAL STUDY
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 2
Abstract
Introduction- Allergic rhinitis (AR) and allergic asthma are caused by an IgE-mediated inflammatory reaction and treatment of AR symptoms requires a stepwise approach depending on the severity and duration of symptoms. A combination of Levocetirizine which is selective, potent, oral histamine H (1) receptor antagonists and Montelukast which is a selective and orally active cysteinyl leukotriene-receptor antagonist (LTRA) is used for the treatment of Allergic rhinitis and Asthma. This Phase IV study trial evaluates the efficacy and safety of the combination of Levocetirizine and Montelukast for the treatment of Allergic Rhinitis or Allergic Asthma. Methodology- Total 270 patients were recruited for the study, of which 256 patients completed the study trial and 14 patients were lost to follow up. Assessment of the efficacy was made by the reduction in TSS and four point Likert-type scales. Safety assessment was done by analyzing the adverse events during the trial. Results- The reduction in TSS from 6.61 (baseline) to 2.94 (day 5) and 0.71 (day 10) was observed. 49 episodes of adverse events occurred and reported which were of mild intensity. Conclusion- A combination of Levocetirizine and Montelukast is safe and effective in the treatment of Allergic Rhinitis or Allergic Asthma.
Authors and Affiliations
Dr. Mayuresh Kiran
Keywords
Related Articles
- EP ID EP670327
- DOI -
- Views 144
- Downloads 0
EFFECTS OF NEO VITACAINTM INSTELLATE GANGLION BLOCK
The purpose of this study was to compare prospectively the effects of Neo VitacainTM (dibucaine 5 mg (0.1%), sodium salicylate 15 mg (0.3%), and calcium bromide (0.2%)) with local anesthetics in stellate ganglion block (...
AMAZING ROLE OF SELENIUM IN BIOLOGICAL SYSTEM
Selenium is essential trace element, sulphur analogue with high chemical activity, component of some selenoproteins and enzymes: glutathione peroxidase and other peroxidases, blood and tissue proteins. As to their biolog...
REVIEW OF BHALLATAKA AND ITS TOXICITY
Semecarpus anacardium Linn.(Family: Anacardiaceae), commonly known “Bhallataka” or “Bhilwa” is a plant well-known for its medicinal value in ayurvedic and siddha system of medicine, It is also popularaly used in tribal a...
PROTECTIVE EFFECTS OF BOERHAVIA DIFFUSA LINN. (NICTAGINACEAE) ON LIVER OF STREPTOZOTOCIN-INDUCED DIABETIC RATS
The aim of this study was to evaluate the hepatoprotective of Boerhavia diffusa Linn. used in Benin and other countries to manage control and treat diabetes. Streptozotocin (STZ) is selectively toxic to cells in the panc...
ANLYTICAL STUDY ON SROTAS
Ayurveda the science of life emphasize on the importance of healthy life for achievement of Purusartha Chatustaya viz. Dharma, Artha, Kama, & Moksha. Holistic approach of Ayurveda is regarded to help for the upliftment o...