Safety and immunogenicity of Bluetongue polyvalent vaccine in sheep and goats
Journal Title: IOSR Journal of Agriculture and Veterinary Science (IOSR-JAVS) - Year 2018, Vol 11, Issue 3
Abstract
Bluetongue (BT) is a non-contagious, arthropod transmitted viral disease of domestic and wild ruminants caused by bluetongue virus (BTV), the prototype member of the genusOrbivirusin the family Reoviridae. In India, the disease was first reported in Maharashtra in 1964. In South India, bluetongue disease occurs annually while sporadic outbreaks occur elsewhere in India. The immunization of susceptible sheep is the most effective and practical control measure against BT. In the present study, 25 sheep and 25 goats of either sex aged more than 4 months which tested negative for BTV antibodies were enrolled. In each species, twenty animals were vaccinated subcutaneously each with bluetongue polyvalent vaccine and five animals acted as controls. Vaccine group animals were administered a booster dose of vaccine on 28th day, while the control group animals received normal saline. Animals were observed for local or systemic reactions after vaccination as well as during the study period. Blood samples were collected on 28th day and 60th day post-vaccination for antibody response. The results revealed that the bluetongue polyvalent vaccine is safe with good immune response in both sheep and goats.
Authors and Affiliations
Dr. V. Surya Prasad, Dr. Y. Narasimha Reddy, Dr. K. Srinivas, B. Sushmitha
Keywords
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