SAFETY ASSESSMENT OF PARTIALLY PURIFIED HDL ENHANCING PHYTOCOMPONENTS FROM DESMODIUM GYRANS DC.

Journal Title: International Journal of Advanced Research (IJAR) - Year 2018, Vol 6, Issue 1

Abstract

Desmodium gyrans (Fabaceae) is a less explored plant belonging to medicinally important genera Desmodium. A recent investigation has reported hypolipidemic and HDL enhancing efficacy of crude alcoholic extract (DGM) of the whole plant. Chromatographically purified aqueous fraction (DGMAF) rich in terpenoids and phenolics exhibited HDL enhancing and reverse cholesterol transport (RCT) promoting activity that may impart atheroprotective potential to this active fraction. Present study was aimed to evaluate the acute and sub-acute oral toxicity of DGMAF in Wistar rats of either sex following OECD guide lines to ensure its safety upon long term exposure. Acute oral dose of 5g/kg body weight did not produce any behavioural abnormality, weight changes or mortality over 14 day period. Necropsy studies revealed no incongruity to internal organs. Further, oral sub-acute doses of 100, 250, and 500 mg/kg body wt for 60 days did not show reduction in body and organ weight, food and water intake. Hematological parameters and biochemical analytes inclusive of hemoglobin, urea, creatinine, total and direct bilirubin, serum GOT, GPT, and ALP did not show statistically significant differences between the untreated control and treated groups. No morphological changes were observed in the histological analysis of the major vital organs including liver, kidney, spleen and intestine. The result of this study thus suggests that DGMAF might be non-toxic at normal therapeutic doses.

Authors and Affiliations

M. S. Indu, Jose Padikkala, Achuthan C . Raghavamenon

Keywords

Related Articles

SOME FEATURES OF EXISTENTIAL SENTENCES IN LANGUAGES BELONGING TO DIFFERENT LANGUAGE SYSTEMS.

The article deals with the main features of existential sentences in English, Azerbaijani and Russian languages. The author makes such an inference that the existential sentences are of universal nature from semantic poi...

THE VULNERABILITY OF MAIZE PRODUCTIVITY BASED ON WATER BALANCE AND CLIMATE DYNAMICS FLUCTUATIONS IN GORONTALO PROVINCE.

There is a vulnerability with correction in maize production if happened water stress due to fluctuations in water balance and climate dynamics in Gorontalo Province. This study aims to determine the vulnerability of mai...

RISK FACTORS FOR CONGENITAL ANOMALY: ANALYSIS AT SBMCH.

Congenital anomalies are a leading cause of infant death and disability and their incidence varies between ethnic group.. Congenital anomalies affect a remarkable proportion of newborn population and contribute significa...

THE ERA OF CLOUD COMPUTING: A RECENT SURVEY.

Cloud computing an emerging technology provides various services to the users like infrastructure, hardware, software, storage etc. For working cloud in data security, it is necessary that cloud computing network should...

A NOVEL AND HYBRID PROTOCOL FOR WIRELESS BODY AREA NETWORKS.

The applications of wireless sensors/body area networks comprise a wide variety of scenarios. In most of them, The Networks is composed a large number of nodes deployed in an extensive are in WSN.It is quite necessary th...

Download PDF file
  • EP ID EP276773
  • DOI 10.21474/IJAR01/6430
  • Views 71
  • Downloads 0

How To Cite

M. S. Indu, Jose Padikkala, Achuthan C . Raghavamenon (2018). SAFETY ASSESSMENT OF PARTIALLY PURIFIED HDL ENHANCING PHYTOCOMPONENTS FROM DESMODIUM GYRANS DC.. International Journal of Advanced Research (IJAR), 6(1), 210-217. https://europub.co.uk/articles/-A-276773