SAFETY OF BIOLOGICS FOR THE TREATMENT OF AUTOIMMUNE DISEASES: A CROSS-SECTIONAL STUDY FROM SAUDI ARABIA
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 9
Abstract
Purpose: This cross-sectional study explored the safety of biological therapies, association between patient characteristics, adverse events (AEs) and biological therapy among treated patients and assess patient-perceived treatment effectiveness of the biologics in autoimmune diseases (AD) patients in Riyadh, Saudi Arabia. Methods: AD patients (ulcerative colitis [UC] and Crohn’s disease [CD], rheumatoid arthritis [RA], and psoriasis [PsO]) who received adalimumab, infliximab, rituximab, or etanercept were analyzed. Results: Of the 115 biologically-treated AD patients (CD=80; RA=18; UC=16; PsO=1), 88.7% received infliximab. Over 95% of the patients experienced at least one AE, with higher prevalence in infliximab cohort than other cohorts. Most common AEs were weight gain (20%–57.1%), hair loss (20%–42.8%), and stomach pain (14.3%–22.6%). Infections occurred in 16.5% of patients; acute nose, throat, and sinus infections and urinary tract infections were the most common infections. There was a lack of association between the variables, biological therapy, and AEs among the treated AD patients. Majority of the treated-patients (89%) reported improvement after treatment with biological therapy; 92% expressed their willingness to continue with the prescribed biological therapy. Conclusions: This study provides valuable data on the safety and patient perceived treatment effectiveness of biologics used for the treatment of various AD.
Authors and Affiliations
Dr. Lamya Al Naim
Keywords
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