SAFETY OF BIOLOGICS FOR THE TREATMENT OF AUTOIMMUNE DISEASES: A CROSS-SECTIONAL STUDY FROM SAUDI ARABIA
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 9
Abstract
Purpose: This cross-sectional study explored the safety of biological therapies, association between patient characteristics, adverse events (AEs) and biological therapy among treated patients and assess patient-perceived treatment effectiveness of the biologics in autoimmune diseases (AD) patients in Riyadh, Saudi Arabia. Methods: AD patients (ulcerative colitis [UC] and Crohn’s disease [CD], rheumatoid arthritis [RA], and psoriasis [PsO]) who received adalimumab, infliximab, rituximab, or etanercept were analyzed. Results: Of the 115 biologically-treated AD patients (CD=80; RA=18; UC=16; PsO=1), 88.7% received infliximab. Over 95% of the patients experienced at least one AE, with higher prevalence in infliximab cohort than other cohorts. Most common AEs were weight gain (20%–57.1%), hair loss (20%–42.8%), and stomach pain (14.3%–22.6%). Infections occurred in 16.5% of patients; acute nose, throat, and sinus infections and urinary tract infections were the most common infections. There was a lack of association between the variables, biological therapy, and AEs among the treated AD patients. Majority of the treated-patients (89%) reported improvement after treatment with biological therapy; 92% expressed their willingness to continue with the prescribed biological therapy. Conclusions: This study provides valuable data on the safety and patient perceived treatment effectiveness of biologics used for the treatment of various AD.
Authors and Affiliations
Dr. Lamya Al Naim
Keywords
Related Articles
- EP ID EP672892
- DOI -
- Views 150
- Downloads 0
NP1600 EFFECT ON CHANGE IN BIOCHEMICAL PARAMETERS IN BROILERS
This study examines the effect of NP1600 on the variation in biochemical parameters (total cholesterol, triglycerides, urea, creatinine, total protein and uric acid) in broiler chickens. A total of 15 chickens was divide...
PHARMACOVIGILANCE AT UNIVERSITY TEACHING HOSPITAL SOURO SANOU : STUDY OF SPONTANEOUS REPORTS OF ADVERSE DRUG REACTIONS
Introduction: Drugs can cause unwanted adverse effects even at normal dosages. The objective was to study the adverse effects related to medication at University Teaching Hospital Souro SANOU of Bobo-Dioulasso (CHUSS), B...
VALIDATED CAPILLARY ZONE ELECTROPHORESIS APPROACH FOR SIMULTANEOUS SEPARATION AND DETERMINATION OF HEPATITIS C SOFOSBUVIR AND LEDIPASVIR IN TABLET DOSAGE FORM
Our strategy in this study concerned with the development of a simple, highly sensitive and precise capillary zone electrophoresis method for the simultaneous separation and quantification of hepatitis C drugs sofosbuvir...
PHYTOCHEMICAL AND ETHNOPHARMACOLOGICAL REVIEW OF TUDRI SURKH (CHEIRANTHUS CHEIRI)
Background and Aims: The traditional system of medicine continues to play an essential role in health care management. A number of plant origin drugs are utilized in Unani system of medicine for the treatment of various...
PREVALENCE STUDY OF SELF -MEDICATION PRACTICE USED AMONG NURSING WORKERS IN IBN SINA HOSPITAL IN COAST HADHRAMOUT GOVERNATE –YEMEN.
Background: Self medication is a major form of self-care It involves the use of medicinal products by the consumer to treat self recognized disorder, symptoms, recurrent disease or minor health problems.[1] Self-medicati...