SAFETY OF BIOLOGICS FOR THE TREATMENT OF AUTOIMMUNE DISEASES: A CROSS-SECTIONAL STUDY FROM SAUDI ARABIA
Journal Title: World Journal of Pharmaceutical Research - Year 2019, Vol 8, Issue 9
Abstract
Purpose: This cross-sectional study explored the safety of biological therapies, association between patient characteristics, adverse events (AEs) and biological therapy among treated patients and assess patient-perceived treatment effectiveness of the biologics in autoimmune diseases (AD) patients in Riyadh, Saudi Arabia. Methods: AD patients (ulcerative colitis [UC] and Crohn’s disease [CD], rheumatoid arthritis [RA], and psoriasis [PsO]) who received adalimumab, infliximab, rituximab, or etanercept were analyzed. Results: Of the 115 biologically-treated AD patients (CD=80; RA=18; UC=16; PsO=1), 88.7% received infliximab. Over 95% of the patients experienced at least one AE, with higher prevalence in infliximab cohort than other cohorts. Most common AEs were weight gain (20%–57.1%), hair loss (20%–42.8%), and stomach pain (14.3%–22.6%). Infections occurred in 16.5% of patients; acute nose, throat, and sinus infections and urinary tract infections were the most common infections. There was a lack of association between the variables, biological therapy, and AEs among the treated AD patients. Majority of the treated-patients (89%) reported improvement after treatment with biological therapy; 92% expressed their willingness to continue with the prescribed biological therapy. Conclusions: This study provides valuable data on the safety and patient perceived treatment effectiveness of biologics used for the treatment of various AD.
Authors and Affiliations
Dr. Lamya Al Naim
Keywords
Related Articles
- EP ID EP672892
- DOI -
- Views 177
- Downloads 0
NANOMEDICINE AND IT’S APPLICATIONS IN CANCER TREATMET
Nanotechnology, although not a new concept, has gained significant momentum in recent years. The prefix ‘nano’ is derived from a Greek word, which means dwarf. The term nanotechnology describes the fabrication of new mat...
EPIDEMIOLOGY OF VITILIGO AND ASSOCIATED AUTOIMMUNE DISEASES AMONG PATIENTS ATTENDING DERMATOLOGY CLINICS IN AL-MADINA 2016 -2017
Background: Vitiligo is a common skin disorder that affects 1% of the whole world population, little is known about vitiligo prevalence and it is subtypes in Al Madinah, Saudi Arabia. Objective: To estimate the prevalenc...
PHARMACOGNOSTICAL AND PHYTOCHEMICAL EVALUATION OF ROOT OF SIDA SPINOSA LINN
Three species are taken as Nagbala by different scholars i.e. Sida humilis cav, Grewia hirsuta, Sida spinosa Linn. It is necessary to study all 3 species to confirm for effectiveness of their immunomodulatory activity. S...
EVALUATION OF SENSORY CHARACTERISTIC (TASTE AND TEXTURE) BY USING DIFFERENT METHODS OF COAGULATION
Concerning the taste, the points attained when using renin, Osher (50%) and Jibeen (50%) enzymes, 8.08± 0.71, 6.25± 0.82, and 7.20± 0.88 respectively. 8.54± 0.77, 5.83± 0,76 and 6.58± 0.71 when using renin, Osher (75%) a...
ELECTROLYTE PROFILE OF MALARIA INFESTED WISTAR ALBINO RATS TREATED WITH THE CRUDE EXTRACT OF ARTEMISIA ANNUA AND ARTEMISININ COMBINATION THERAPY.
Effects of the crude extract of Artemisia annua on the serum electrolyte level of wistar albino rats was assessed in this study. It involved twenty four (24) wistar rats, weighing between 180-220g and distributed into fo...